At the Heart of Every ALS RNA Aggregate, a Single Transcript
In induced cells from people with a C9ORF72 expansion, the number of mutant transcripts matched the number of RNA foci per cell.
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Barfing Up Balls of Trouble Keeps Some Neurons Healthy
Neurons of the humble roundworm pack damaged organelles and protein aggregates into giant vesicles and heave them out into extracellular space. Do our neurons do that, too?
Microbes in the Gut Egg on Aβ Pathology in Mice
Transgenic mouse models devoid of gut microbes make fewer Aβ plaques.
Case Closed: Testosterone Does Not Boost Cognition
A well-controlled trials shows that a year of treatment offers no cognitive benefit for older men with low testosterone levels.
Bizarre Twist on Amyloid Structure
Produced by the dreaded MRSA bacterium, PSMα3 is the first known example of a natural peptide that forms amyloid fibers made not of β-sheets, but of neatly stacked α-helices.
Pee P75: A Potential Biomarker of ALS Progression?
ALS patients eliminate more p75 neurotrophin receptor than do healthy controls. P75 urine levels rise as disease worsens.
Consortium to Seek Biomarkers for Vascular Cognitive Impairment
NIH funds a five-year project to validate biomarkers for clinical trials.
Clinical-Grade Stem Cells Fail to Replicate Benefit of Research Lines
Quality control issues may have scuppered clinical trials.
Mental Training Evokes Superior Memory, Transforms Brain Networks
Mnemonic training reshapes functional connectivity patterns in the brain to facilitate recall akin to that found in memory athletes.
President Proposes Massive Cut to NIH; Potential Fallout for Alzheimer’s Unclear
The proposed budget would strike a blow to biomedical research, and science in general.
ALS Dipeptides Drive Liquid-Liquid Phase Separation, Stress Granule Formation
Route to toxicity converges with RNA binding proteins in membrane-less organelles.
Number of U.K. Dementia Researchers Doubles over Six Years
A report claims that in the U.K. dementia research grew substantially since 2008, but more gains are needed to find treatments.
Tau Immunotherapy for Aβ?
Antibodies against tau lower APP expression and degrade Aβ plaques in transgenic mice.
Does Tau’s Third Repeat Propagate Misfolding in Vivo?
Although shorter tau peptides formed fibrils in a dish, the R3 domain of tau seeded aggregation in cells.
In a First, FDA Approves Deuterated Drug for Huntington’s
By virtue of its heavy hydrogen, deutetrabenazine resists metabolism by liver enzymes, allowing clinicians to better titrate the drug.
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