The Making of a “Superager”: New Research Examines Neuroanatomy that Keeps Older Adults Sharp
Preserved brain networks may explain the exceptional memory prowess of some older adults.
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Grow that Axon: C9ORF72 Function Revealed?
The mysterious protein made by the ALS/FTD-associated gene may regulate the actin filaments that physically support axons.
What Exactly Does BACE Do in Adults?
Researchers at the Kloster Seeon meeting pressed in on the question of what are the physiological functions of this protease after development is complete.
Kloster Seeon meeting on BACE proteases in health and disease
At 2nd Kloster Seeon Meeting, Renewed Optimism for Targeting BACE1 What Exactly Does BACE Do in Adults? BACE Inhibition and the Synapse—Insights from Seeon Does BACE Drive Neurites into Dystrophy, Shorting Circuits? Will Next-Gen BACE Inhibitors Dodge Sid
BACE Inhibition and the Synapse—Insights from Seeon
At the 2nd Kloster Seeon meeting on BACE proteases, researchers linked BACE substrates to regulation of synaptic activity.
Will Next-Gen BACE Inhibitors Dodge Side Effects?
Despite no warning signs in ongoing clinical trials, researchers are searching for safer drugs, and better biomarkers to measure what they do.
Cortical Folds Loosen in Aging and Disease, but Not in the Same Way
In development, the brain follows a set of rules when it folds to form its ridges and grooves. Those rules change with age, and especially in Alzheimer’s.
With Amyloid Scan in Hand, Physicians Manage AD Differently
In Italian memory clinics, the PET scans resulted in diagnosis and medication changes for up to a third of patients.
EMIF, GAAIN: Online Gateways to Reams of Alzheimer’s Data
Two international initiatives compile metadata from aging and AD studies into huge searchable catalogs in hopes of speeding research progress.
Positive Trials of Spinal Muscular Atrophy Bode Well for Antisense Approach
Trial sponsors moved children from ongoing trials to open-label studies following positive interim results of an antisense oligonucleotide treatment.
New Spectroscopy Method Detects Myelin Changes in Early ALS
Before any other changes, the fatty coating on peripheral nerve fibers breaks apart, heralding their degeneration.
New Tracer May Prove Better for Amyloid PET
Fluselenamyl avoids white matter and binds diffuse plaques
Live Monitoring Study Shows Only Blood Insulin Triggers Rise in Brain Aβ
Insulin delivered directly to the brain does nothing to Aβ in an AD mouse model, complicating the relationship between diabetes and Alzheimer’s.
Do Microbes in the Gut Trigger Parkinson’s Disease?
In a PD mouse model, microbes pump out short-chain fatty acids that worsen synuclein aggregation and motor problems. Intestinal flora from people appears to do the same.
Astrocytes and Exosomes Implicated in Protein Propagation
Researchers at SfN 2016 painted a more detailed picture of how misfolded proteins may proliferate, as one cell spreads these “hot potatoes” to the next.
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