Frontotemporal Dementia: The Hard Work of Pushing Toward Trials
With a laser focus on biomarkers and disease mechanisms, researchers at the 10th ICFTD meeting prepared the ground for therapeutic studies.
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International Conference on Frontotemporal Dementias 2016
Frontotemporal Dementia: The Hard Work of Pushing Toward Trials First Round of FTD Therapeutics Fell Short, But Many More Are Up and Running Fluid NfL Shines, Tau PET Dims, in the Hunt for FTD Biomarkers Tests of Social Cognition Hold Potential as FTD Out
First Round of FTD Therapeutics Fell Short, But Many More Are Up and Running
Researchers reported negative findings from three trials at ICFTD 2016.
Fluid NfL Shines, Tau PET Dims, in the Hunt for FTD Biomarkers
Researchers at an international frontotemporal dementia congress reported progress in finding markers that track disease, but no luck thus far with diagnostic markers.
Tests of Social Cognition Hold Potential as FTD Outcome Measures
Several such tests generated enthusiasm at the international frontotemporal dementia congress.
FTD Gene Hunt Turns Up CYLD and Modifying Factors
Geneticists at frontotemporal dementia conference reported a new link with a ubiquitine enzyme and strengthened other gene associations.
New Data Reinforces Concept of Protein Propagation
Sometimes challenged, the idea that pathogenic proteins spread through the brain got a lift from new animal model data presented at the frontotemporal dementia meeting.
STARSHINE Trial Loses its Luster
Idalopirdine failed to slow memory decline in patients with Alzheimer’s disease.
Could a Failed Heart Drug Treat Tauopathies?
In mice, rolofylline perks up neurons laid low by aggregates of tau.
A Levodopa Inhaler for Parkinson’s?
Can sucking in a little extra drug tide patients over until their next dose?
Caspase-2 May Unleash Soluble Toxic Tau Fragment
The fragment crowds into synapses and may drag full-length tau along for the ride. Researchers proposed caspase-2 as a therapeutic target.
The Making of a “Superager”: New Research Examines Neuroanatomy that Keeps Older Adults Sharp
Preserved brain networks may explain the exceptional memory prowess of some older adults.
Grow that Axon: C9ORF72 Function Revealed?
The mysterious protein made by the ALS/FTD-associated gene may regulate the actin filaments that physically support axons.
What Exactly Does BACE Do in Adults?
Researchers at the Kloster Seeon meeting pressed in on the question of what are the physiological functions of this protease after development is complete.
Kloster Seeon meeting on BACE proteases in health and disease
At 2nd Kloster Seeon Meeting, Renewed Optimism for Targeting BACE1 What Exactly Does BACE Do in Adults? BACE Inhibition and the Synapse—Insights from Seeon Does BACE Drive Neurites into Dystrophy, Shorting Circuits? Will Next-Gen BACE Inhibitors Dodge Sid
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