Can Pencil-and-Paper Test Predict Pathology Behind PPA?
Nuances in episodic memory can tell if primary progressive aphasia is due to non-tangle types of tau pathology or to plaques and tangles.
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Loss of Y Chromosome in Blood Tied to Alzheimer’s
Age-related attrition of the male chromosome in blood cells raises the risk of Alzheimer’s disease. Researchers suspect immune cells are compromised.
Barrier Function: TREM2 Helps Microglia to Compact Amyloid Plaques
Mice lacking the receptor have more diffuse plaques, more dystrophic axons, and more neurodegeneration. The TREM2-microglia hail from inside the brain.
Mice Learn but Soon Forget: New Clues for Detecting Preclinical Alzheimer’s?
A study reports that even while young transgenic mice learn just fine, both their memory consolidation and brain glucose metabolism falter before the onset of amyloid plaques.
HIPK2 Clinches Neurons’ Fate in Amyotrophic Lateral Sclerosis
The kinase triggers a death cascade in animal models featuring endoplasmic reticulum stress. Active in ALS patients, it warrants a look as a potential therapeutic target.
Online Course Gives Guidance on How to Lower Dementia Risk
Beginning in July, a massive open online course will summarize research on how to maximize brain health.
Keystone Meeting on Microglia/Neurodegeneration: Here’s the Buzz
A dynamic joint meeting dispels some old tenets while charting new avenues for research, such as microglia from iPSCs.
Keystone Symposia: Common Mechanisms of Neurodegeneration/Microglia in the Brain
Keystone Meeting on Microglia/Neurodegeneration: Here’s the Buzz Induced Microglia Make Debut at Keystone Symposium The THIK and Thin of Microglial Surveillance When a Microglia Is No Longer a Microglia Unbiased Screen Fingers TREM2 Ligands That Promote A
Induced Microglia Make Debut at Keystone Symposium
Three research groups turn induced pluripotent stem cells into what look like microglia.
Unleashed From the Nucleus, TDP-43 Wreaks Havoc in Mitochondria
Loose in the cytoplasm, TDP-43 heads straight for the neuronal powerhouses, sapping their ability to make energy.
German Families with Dominantly Inherited Alzheimer’s Disease Meet for the First Time
Seeking strength in numbers, families gathered to swap stories and to learn about an upcoming DIAN-TU therapy trial geared specifically to their particular form of early onset AD.
TREM2 Helps Phagocytes Gobble Up Aβ Coated in Antibodies
Microglia and macrophages lacking the receptor consumed less amyloid in vitro, even when stimulated by anti-Aβ antibodies.
House Committee Votes to Boost AD Research Dollars
A bill approved by the U.S. House Committee on Appropriations would increase funding for Alzheimer’s by $350 million.
The THIK and Thin of Microglial Surveillance
At Keystone, researchers report the discovery of ion channels that shed light on the machinations of the brain’s microglia.
When a Microglia Is No Longer a Microglia
Researchers are discovering that microglia not only respond dramatically to their environment, but they also can quickly lose their identity.
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