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British researchers report in today’s Science that they have managed to prevent and even reverse clinical manifestations of prion disease. Surprisingly, they did it not by eliminating deposits of abnormal prions, but by...
In today's Science, Cynthia Kenyon and colleagues at the University of California, San Francisco, report that they have generated transgenic nematodes, <em>Caenorhabditis elegans</em>, that live six times longer than normal, the equivalent of about a 500-year lifespan in humans...
In yesterday's Nature, Tobias Baumgart and colleagues shine some light on the fluid dynamics of biomembranes using two-photon microscopy to visualize lipids that separate into coexisting liquid phases, or domains, in giant unilamellar vesicles...
Jeff Rothstein of Johns Hopkins University last Monday chaired a symposium on animal models of neurologic diseases at the American Neurological Association, held in San Francisco from October 19 to 22. Two talks were particularly relevant to this audience...
Sam Gandy Reports from San Francisco on Mouse Models American Neurological Association: 2003 Annual Meeting
The FDA last Friday followed the recommendation of its advisory panel last month and approved memantine for use in moderate to severe AD...
The chemokine receptor CCR1 might be an early and specific marker of Alzheimer's disease, researchers suggest in the November issue of Annals of Neurology, now available online...
In this week's advanced online edition of PNAS, researchers report that presenilin (PS), the aspartyl protease proposed to be the heart of γ-secretase, may function as a dimer...
Interview with Akihiko Takashima, RIKEN Brain Science Institute, Wako, Saitama, Japan
Immune molecules, thought to act exclusively in the periphery presenting antigens and fighting infection, in fact, have an alter ego in the brain's neurons, where they help remodel synapses in response to neural activity. How's this for a wild idea in AD research: Could it be that synapses are attacked in a misguided immune response...
A classic case of scientific serendipity has added an ironic wrinkle to the prion story. An article in today's Nature shows intriguing evidence that prions may indeed need nucleic acids to infect hosts-yet these nucleic acids may come from the host itself...
Shedding light on why mutations in parkin protein might cause familial Parkinson's disease, a study in the October 6 online PNAS shows how overexpression of one of parkin's targets can cause degeneration of dopamine neurons in vivo...
If humans are almost genetically identical to their primate relatives, what is it that makes us smarter? In this week’s PNAS early online edition, researchers suggest that the greater brain power is due to elevated gene expression...
In Alzheimer’s patients, a portion of soluble amyloid-β peptides (sAβ) never makes it out of the brain as in normal subjects, ending up instead in amyloid fibrils or plaques. A trio of recent papers explores factors that determine the fate of these peptides...
One well-characterized cause of amyotrophic lateral sclerosis (ALS) is mutation of the copper-zinc isoform of superoxide dismutase (SOD), causing progressive degeneration of motor neurons. But must these mutations occur in neurons to be detrimental? A report in today’s Science suggests...
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