No Rest for the Weary: Melatonin Fails Alzheimer's Trial
Melatonin does not appear to be useful in helping most Alzheimer's patients achieve a good night's sleep, according to a study in the November issue of the journal Sleep...
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The Quality-of-Life Balance: Anticholinergics in the Hot Seat
A case report in the December 5 issue of the New England Journal of Medicine presents an example of the potential dangers of anticholinergic drugs in some patients: short-term memory loss and hallucinations...
Society for Neuroscience Annual Meeting 2003
New Orleans: Immunotherapy—The Game Is Still in Town New Orleans: New Approaches to Lift Microglia Mysteries New Orleans: Symposium Probes Why Synapses Are Suffering New Orleans: Out Go Classic γ-Secretase Inhibitors, In Come More Dexterous NSAIDs? New Or
New Orleans: Probing Alzheimer’s Gene Background
At the 33rd Annual Meeting of the Society of Neuroscience held last month in New Orleans, <strong>Bruce Lamb</strong> described the latest analysis of his strains of congenic mice that differ by background only—a novel approach to study AD genetics...
Synaptic Activity—Ubiquitination or De-ubiquitination?
The ubiquitin-proteasome system, which operates in almost every eukaryotic cell, has been implicated in the pathogenesis of numerous neurodegenerative diseases. So does this pathway have a specialized role in neurons?...
Yeast Teases Apart Huntington’s and Parkinson’s Protein Aggregation
The accumulation of protein aggregates is a common theme uniting most major neurodegenerative diseases, but does this phenomenon underscore a common pathogenic mechanism?...
New Orleans: Michael O'Neill Reports on Nicotinic Receptors in Parkinson's
A satellite meeting to the 33rd Annual Meeting of the Society for Neuroscience addressed nicotine and nicotinic receptors, and their potential for Parkinson's disease therapy...
New Orleans: Jason Shepherd Reports on New Mouse Models
Two new approaches for modeling neurodegeneration in mice were unveiled at the 33rd Annual meeting of the Society for Neuroscience in New Orleans...
Radical Development: Reactive Oxygen Species Critical in Development
A paper in the December 5 issue of Science offers some clues about the manifold roles that ROS play in signaling pathways during embryonic development...
New Orleans: Kelly Dineley Reports from Satellite Social
At the Society for Neuroscience meeting in New Orleans, approximately 100 scientists gathered to discuss what roles the interaction between Aβ and the nicotinic acetylcholine receptor (nAChR) play in normal cognitive function and Alzheimer's disease...
New Orleans: Plant Chemical a Protein Aggregation Buster?
At the 33rd Annual Meeting of the Society for Neuroscience, Anthony Fink and M. Zhu of the University of California, Santa Cruz, reported that baicalein, a flavanoid used in traditional Chinese medicine, binds tightly to α-synuclein and even disaggregates...
New Neurons Born among the Dying in Alzheimer’s Hippocampus?
Is the cycle of life—new lives born even as the old die—to be found in the hippocampus of Alzheimer's patients? A study in this week’s online PNAS suggests just this, and poses the question of...
New Orleans: Aβ Oligomers and Memory: Now They Are Good…
As evidence mounts against oligomers as culprits of Aβ neurotoxicity, their only defense hinges on the possibility that they may have some normal physiological function—even a slightly neurotrophic effect—on cognition which has yet to be characterized...
New Orleans: Aβ Oligomers and Memory: …Now They Are Bad
Notwithstanding some redeeming features, soluble Aβ oligomers have an overwhelmingly bad reputation as suspected mediators of synaptic dysfunction in Alzheimer’s. A number of accusing fingers...
New Orleans: Out Go Classic γ-Secretase Inhibitors, In Come More Dexterous NSAIDs?
Eric Parker from the Schering-Plough Research Institute in Kenilworth, New Jersey, reported at the Society for Neuroscience meeting in New Orleans what many may have heard already: At least some γ-secretase inhibitors cause mechanism-based side effects so severe as to disqualify them from clinical testing...
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