Could Kink in Tau Lead to Neurodegeneration?
Findings suggest a severe blow to the head twists the protein's backbone, which may lead to neurofibrillary tangles.
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Divvying Up the Ice-Bucket Dollars: Challenge Speeds Trials, Research
A year after social media campaign, what happened with the money?
Alzheimer's Association International Conference 2015
Massive Mouse Study Bolsters Rationale for Combination Therapy TREM2 Tidbits at AAIC: Genetics, Clinical Data New Data on Autosomal-Dominant Alzheimer’s Point to Early Fissures in the Brain’s Microarchitecture Aducanumab, Solanezumab, Gantenerumab Data Li
Could “Brain-Only” Estrogen Treat Symptoms of Menopause?
Enzyme converts pro-drug to estradiol in the cortex and hippocampus.
TREM2 Tidbits at AAIC: Genetics, Clinical Data
Probing this this Alzheimer’s risk factor, scientists find a novel variant, but no consensus yet on how this cell surface receptor increases risk for disease.
100 DIAN Family Members Gather for Their First International Meeting
A sense of shared purpose energized a day of exchange between families with autosomal-dominant AD and researchers engaged in the Dominantly Inherited Alzheimer Network.
At DIAN Family Meeting, Funding News Caps Talk of Inadequate Services
Bypass budget promises tide may be turning on an underfunded disease as families with autosomal-dominant Alzheimer’s discuss how to navigate their daily challenges.
Families Challenge DIAN Scientists to Do Even More, Faster
Regulatory and pharma scientists fielded pleas from families with autosomal-dominant Alzheimer’s disease just prior to the AAIC conference.
Alzheimer's Association International Conference 2015: ADAD Family Conference
100 DIAN Family Members Gather for Their First International Meeting At DIAN Family Meeting, Funding News Caps Talk of Inadequate Services Families Challenge DIAN Scientists to Do Even More, Faster Throughout the five days of the 2015 Alzheimer's Ass
New Data on Autosomal-Dominant Alzheimer’s Point to Early Fissures in the Brain’s Microarchitecture
Tiny injuries to capillaries in white matter, and to cells in gray matter, have come to be the focus of new imaging measures being explored in early presymptomatic AD.
Aducanumab, Solanezumab, Gantenerumab Data Lift Crenezumab, As Well
At AAIC, new data on three anti-Aβ antibodies reinforced a sense of hope that Aβ immunotherapy may yet work out. Challenges with each antibody notwithstanding, all four leading candidates, including crenezumab, are now in Phase 3.
Prion Stabilizers Boost Survival in Infected Mice—What About Other Proteinopathies?
Polythiophene compounds stabilized prions and prevented them from spreading through the brains of infected mice. Researchers predicted the compounds could work on Aβ and tau, too.
Exercise Boosts Cognition In Symptomatic Disease
At the right intensity and treatment duration, aerobic exercise can sharpen thinking skills and improve brain function even in cognitively impaired people, say researchers.
Can Exercise Slow the Progression of Alzheimer’s Pathology?
Researchers report multiple benefits of aerobic exercise on brain function, including some hints it could slow tau pathology.
CSF Aβ Assays Remain Fickle: Robots to the Rescue?
Variability still plagues CSF biomarker measurements, but automated systems offer hope of a diagnostic assay.
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