Injectable Electronics Unfold in the Brain, Record Neurons
Tiny mesh electronics fold up neatly into the needle of a syringe and can be injected into the brain. The devices record neurons, and may do more in the future.
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Synaptic Genes Determine Brain Connectivity
A new approach identifies a set of synaptic genes that influence the strength of connections in large brain networks.
ApoE4 Paper Retracted from Nature
One author falsified figures, prompting the lab to request a retraction.
New Substrate Ties γ-Secretase to Immune Function
The enzyme complex directly cleaves a protein crucial for survival of B cells, debuting a new type of substrate for the protease.
No C9ORF72, No Problem: Knockout Mouse Neurologically OK
The mice, which lack the ALS- and FTD-linked gene in neurons, indicate that C9ORF72 loss of function alone cannot cause neurodegeneration.
Synapses Found to Vanish on Same Time Scale as Memories
Live imaging combined with mathematical modeling suggests that dendritic spines in the hippocampus disappear on the same time schedule as short-term memories fade.
The Cerebral Cortex Folds Like Paper
The scale of cortical folding in mammals—from rodents to humans—is dictated by a simple relationship between surface area and thickness.
MAO-B Inhibitor Misses Primary Endpoint
A Phase 2b trial finds that the monoamine oxidase B inhibitor sembragiline missed its primary endpoint.
For Episodic Memory, Neurons Quickly Change Their Tune
By recording from individual human brain cells, researchers find that single neurons can instantly encode associations, showing how rapidly they form memories.
Novel Methylation Distinguishes Neuron Types, May Dictate Disease
Methylation of cytosines that do not precede guanine bases in DNA prominently occurs in the brain, but not the rest of the body. This epigenetic mark may play a role in Rett syndrome.
β2-Microglobulin: A Blood-Borne Aging Factor?
A protein that accumulates in the blood of old mice impairs memory and neurogenesis.
Legal Tussle Threatens to Embroil ADCS
The University of California, San Diego, is suing the University of Southern California and Alzheimer scientists.
Juvenile Lysosomes and Worn-Out Mitochondria Clog Axons in ALS Model
Mutant SOD1 prevents immature lysosomes from traveling along the axon and from maturing, leaving the cell with no means to clear broken-down mitochondria.
2015 MetLife Awards Go To Haass, Bateman
The foundation recognizes the two researchers for their work on the molecular underpinnings Alzheimer’s disease.
With Mirrors, but No Smoke, Skull Performs Vanishing Act
Clever optical corrections reveal microglia and neurons through the intact mouse cranium.
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