Gamma Secretase: Intramembrane Liaisons Revealed
Researchers report the highest resolution structure to date for γ-secretase, the multisubunit complex that churns out Aβ.
ALL NEWS
6538 RESULTS
Sort By:
- Most Recent
- Most Commented
New PET Tracer Tracks Preclinical Movement Disorders
Several different striatal markers may help researchers track early deterioration in Huntington's and Parkinson’s diseases.
American Academy of Neurology: 2015 Annual Meeting
Davies, Sperling Share 2015 Potamkin Prize New PET Tracer Tracks Preclinical Movement Disorders Neurodegenerative Proteins in the Skin Could be Diagnostic The 67th American Academy of Neurology conference drew more than 12,000 attendees to Washington, D.C
No FUS, No ALS: Gain of Toxic Function Likely MO of Mutations
Knockout mice lived to old age with mild brain abnormalities but no sign of motor neuron disease.
Do BACE Inhibitors Activate Microglia?
A discontinued β-secretase blocker reportedly quieted inflammation and cleared amyloid plaques by way of microglial activation.
New Wrinkle in APP Processing: Does C-Terminus Increase Tau Pathology?
A stem cell model suggests the β-secretase-generated C-terminal fragment of the amyloid precursor protein raises tau protein levels.
Danger, S-Bends! New Structure for Aβ42 Fibrils Comes into View
Aβ42 molecules assume an S-shaped configuration within fibrils. The structure varies markedly from that adopted by Aβ40.
Neurodegenerative Proteins in the Skin Could be Diagnostic
Scientists find neurodegenerative proteins squirreled away in the skin cells of patients. Could this present an untapped source of biomarkers?
Research Summit 2015 Recommendations Released
A revised plan of action for AD research has emerged from the Alzheimer’s Disease Research Summit 2015.
In Optogenetic Mouse, Neural Activity Drives Up Amyloid Deposition
Repeated activation of the perforant pathway over five months doubled the area of amyloid plaques in transgenic mice.
Startup Brings $217 Million to Neurodegenerative Disease Research
Denali Therapeutics gets off the ground with one of the largest Series A rounds ever.
Crucial Cluster: MicroRNAs Keep Motor Neurons Alive
The motor neurons most sensitive to ALS require a microRNA cluster to survive, lest PTEN activates apoptosis.
Does Amyloid Disturb the Slow Waves of Slumber—and Memory?
A new study reports that Aβ disturbs sleep patterns that help cement memories.
Double Dose of Prion Variant Blocks Disease
A genetic polymorphism in the human prion protein that shielded cannibalistic tribe members from the disease kuru could help researchers understand the structural biology of Creutzfeldt-Jacob disease.
Arizona Research Center to Focus on Neurodegenerative Disease
Arizona State University and Banner Health are hiring 20 scientists and their teams for a joint research institute dedicated to neurodegenerative diseases.
Current Filters
No filters selected