Memory Maker or Neuron Killer? For Transcription Factor, It May Depend on Mood
Blamed for neurodegeneration and memory problems, the transcription factor ATF4 may also be a gatekeeper for synaptic plasticity and memory formation.
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Protein Propagation Real, but Mechanisms Hazy
Researchers no longer debate whether misfolded proteins spread through the brain in neurodegenerative disease. Now they want to know how.
Estrogen-like Receptor: The Gas Pedal of the Brain?
Scientists have found that the nuclear receptor ERRγ ramps up mitochondrial energy production in neurons.
The Feud, Act II: Do Alzheimer’s Genes Affect Amyloid or Tau?
Researchers link the AD Risk gene BIN1 to tau and amyloid in different model systems, and propose a mechanism for how a PICALM variant might be protective.
Could Viral Infections Instigate Juvenile ALS?
Senataxin, a gene associated with early onset ALS, regulates how cells respond to viruses.
The PLD3 Gene: Alzheimer's Risk Factor or False Alarm?
Four new studies call into question PLD3’s status as an AD risk factor. Larger studies may be needed to settle the debate.
Beware That Toast: Gluten Sensitivity in Some People with ALS?
In a preliminary study, 15 percent of people with ALS had antibodies against an enzyme that processes the wheat protein gluten.
Deep Brain Stimulation: It’s All About the Rhythm
Deep brain stimulation helps many people with Parkinson’s, but how it does so remains a mystery. A new study suggests it normalizes brain rhythms.
In ALS, Astrocyte TGF-β1 Pulls Rug From Under Motor Neurons
The growth factor turns off microglia, major support cells for neurons.
Microglia—Who Are You Really? New Clues Emerge
At AD/PD, researchers further tied TREM2 to phagocytosis and enumerated markers that may distinguish beneficial microglia from harmful ones.
Tau Triple Threat: Do Trimers Make Bad Seeds?
A new study suggests that tau oligomers as small as trimers enter neurons and corrupt native tau proteins inside.
Davies, Sperling Share 2015 Potamkin Prize
In a Solomonic move, a prestigious prize for research in neurodegenerative disease goes to a veteran tauist and a self-professed inhabitant of “amyloid land.”
An Axon Self-Destruct Button Triggers Energy Woes
A protein instigates axon degeneration by promoting destruction of the essential enzyme cofactor, NAD+.
DIAN-TU Pharma Consortium NexGen Trial Meeting
As DIAN Plans Trial Number Two, the Goal Is to Go Big DIAN-TU Pharma Consortium NexGen Trial Meeting
Do Extended Species of Aβ Poison Synapses, Masquerade As Dimers?
Researchers identify N-terminally extended Aβ peptides that are toxic to synapses and rise after BACE1 inhibition, though whether they occur in human disease remains unclear.
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