Second Study Salutes TANK-Binding Kinase 1 as ALS Gene
Approximately 4 percent of familial ALS cases may be due to TBK1 mutations.
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Design From Disorder: New Test Reveals Different Strains of SOD1
A novel assay detected two strains of human SOD1 in mice expressing the protein. They differed from those that formed in vitro. Researchers hope to use the technique to identify strains of other problem proteins as well.
Small Brain Bleeds Lead To Bigger Problems in Alzheimer’s
Microbleeds in the brain portend either stroke or cardiovascular events, depending on where they occur.
International Conference on Alzheimer's & Parkinson’s Diseases 2015
Biogen Antibody Buoyed by Phase 1 Data and Hungry Investors Antibody Against α-Synuclein Looks Safe In Phase 1 At AD/PD Meeting, New BACE Inhibitor Struts Its Stuff D-peptides as Drugs? Protein Therapy Approaching Phase 1 Trials New Genetics Frontiers: Fi
Antibody Against α-Synuclein Looks Safe In Phase 1
Treatments targeting the main pathological protein of Parkinson’s disease are moving toward the clinic, with two immunotherapies passing Phase 1 safety benchmarks.
At AD/PD Meeting, New BACE Inhibitor Struts Its Stuff
The newest contender in the race for a drug to rein in the β-secretase enzyme debuted with data that reflected a methodical approach to understand a drug’s performance in cerebrospinal fluid before looking for efficacy.
Methyl Groups Put the Brakes on FTD Progression
Epigenetic changes in the C9ORF72 promoter do not prevent disease, but they do decelerate brain atrophy and memory loss.
More Alzheimer’s Journals Starting Up This Spring
Two new open-access journals will cover specialized areas of Alzheimer’s research.
Could Tumor Suppressor p53 Promote Proteostasis?
A screen in round worms identifies a novel mechanism for degradation of toxic proteins.
FDA Gives a Nod for Alzheimer's and Parkinson's Biomarkers
Qualification could follow, but only if trial sponsors fork over fresh data.
Amplitude Modulation—Do MicroRNAs Muffle Noise in Gene Expression?
By dampening translation, these tiny RNAs keep protein levels from fluctuating wildly.
Amyloid Measures Predictably at Odds on Ends of Scales
The highs and lows of cerebrospinal fluid Aβ and PET amyloid imaging don't necessarily agree.
D-peptides as Drugs? Protein Therapy Approaching Phase 1 Trials
Peptides made from D-amino acids bind to Aβ oligomers and trigger their removal from the brain. Some appear poised to enter Phase 1.
New Genetics Frontiers: Finding Modifiers, Making Sense of Pathways
At the AD/PD conference, researchers reported a protective gene variant that delays Alzheimer’s onset by 10 years, and parsed pathways to find out why particular neurons take the hit in specific diseases.
Form and Function: What Makes α-Synuclein Toxic?
New data argue that multimers of α-synuclein may protect against pathological aggregation.
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