Microglia Kick Off Inflammatory Chain Reaction
The brain’s resident immune cells secrete galectin-3, which activates other nearby microglia to promote neuroinflammation.
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Seizures in BACE1 Knockouts: Are Potassium Channels to Blame?
In mice lacking BACE1, fewer potassium ions escape hippocampal neurons, causing brain cells to fire more rapidly.
Stop, Hey, What’s That Sound?... Amyloid Is Going Down?
When ultrasound opens the blood-brain barrier in mice, microglia engulf plaques.
Stem Cells Reveal Mechanism Behind Alzheimer’s Risk Factor
Risk alleles of SORL1 dampen its expression in response to growth factors, leading to higher Aβ production.
Expansion and Methylation Go Hand in Hand in C9ORF72
The ALS- and FTD-linked expansion, once it reaches more than 90 repeats, always manifests methyl groups.
RNA-Binding Protein Controls Ataxin-1 Expression
Similar regulators could be the next frontier in neurodegeneration studies, scientists say.
Microglia Rely on Mixed Messages to Select Synapses for Destruction
Researchers at a Keystone meeting reported that a combination of protective and destructive signals target microglia to prune synapses in the brain. These signals may be altered during disease.
About-Turn—In Mouse Model of Down’s Syndrome, Inhibitory Neurotransmitter Excites
A chloride ion imbalance renders γ-aminobutyric acid (GABA) receptors excitatory.
$100 Million Dementia Discovery Fund to Stimulate Drug Research
The British government, pharmaceutical companies, and a research charity establish a venture capital fund.
Living on the Edge: Moderately Low Aβ42 in CSF Predicts Decline
Cognitively normal people with levels of CSF Aβ42 near the cutoff point associated with amyloid pathology are likely to cross that threshold within three years.
More Evidence That Epilepsy Drug Calms Neurons and Boosts Memory
Phase 2 trial data show promise, say researchers.
Motor Neuron Vulnerability: The Case of the Missing Chaperone?
Motor neurons may be susceptible to ALS because they lack a chaperone that folds SOD1.
44 Parent-Child Trios Yield 40 Candidate ALS Genes
Researchers found inherited recessive or dominant de novo mutations in people with sporadic ALS whose parents did not have the disease.
Biogen Antibody Buoyed by Phase 1 Data and Hungry Investors
Antibody against aggregated Aβ reported to clear out amyloid from brain, and perhaps slow cognitive decline, in people with prodromal Alzheimer’s disease.
Massive Icelandic Genome Analysis Offers Clues to Health and Disease, Including AD
Sequences of more than 2,600 Icelanders link loss-of-function mutations in the ABCA7 gene to increased risk for Alzheimer’s.
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