Lumbar Puncture: Heading Off the Dreaded Headache
Spinal taps have a bad rap. Are headaches really all that common afterwards, and are there ways to prevent them?
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MAPping Death Pathways in Axons
The classic kinase cascade conspires to commit programmed axonal degeneration after injury.
Structure of Microglial Receptor Offers Clues for PET Ligand Design
For the first time, scientists report a crystal structure of TSPO, a potential target for PET imaging of neuroinflammation.
Voilà SorLA! Sorting Receptor’s Structure Solved
Scientists have produced an atomic-level picture of a receptor implicated in both the sporadic and familial forms of Alzheimer’s.
Human Amyloid Imaging Meeting Was Abuzz With Talk of Tau
The field of tau PET is growing rapidly as the leading tracer T807/AV1451 is more widely used and new compounds from Japan and Switzerland enter the scene with clinical trials of their own.
Human Amyloid Imaging 2015
Human Amyloid Imaging Meeting Was Abuzz With Talk of Tau Tau Tracer T807/AV1451 Tracks Neurodegenerative Progression Tau PET Fits With CSF, Grows Over Time, Picks up Frontotemporal Cases What If It’s Not Garden-Variety AD? Telling Variants Apart by Where
In Fruit Flies, MicroRNA Protects Synapses Against Excitotoxicity
Loss of the microRNA leads to glutamate toxicity and neurodegeneration.
Tau Tracer T807/AV1451 Tracks Neurodegenerative Progression
Data come tumbling in as more people are getting scans with the first widely used tau PET tracer. Scientists at HAI were pleased by how closely degeneration and symptoms match up in Alzheimer’s.
Tau PET Fits With CSF, Grows Over Time, Picks up Frontotemporal Cases
Early data suggest that the T807/AV1451 signal relates to cerebrospinal biomarkers of Alzheimer’s, intensifies by up to 10 percent a year, and might nail diagnoses beyond typical AD.
Mixed Bag on Tau Tracer Validation, Kinetics: Some Things Fit, Some Don’t
Autoradiography confirms that T807/AV1451 binds tau but not TDP-43. Even so, some say the tracer will benefit from more technical work to ensure it will measure small changes robustly in multicenter settings.
Keystone Symposium: Alzheimer's Disease 2006
Keystone Symposia Meeting, Part 1—Alzheimer’s Disease: Genes, Cellular Pathways and Therapies Keystone Symposia Meeting, Part 2—Genetics and Epidemiology of AD Keystone Symposia Meeting, Part 3—Amyloid Precursor Protein Function Keystone Symposia Meeting,
Let’s All Move to Iceland: Anti-Dementia Allele Rare in U.S.
An APP variant reported to stave off Alzheimer’s disease occurs in about one in 6,500 Americans.
Keystone Symposium: Neuroinflammation in Diseases of the Central Nervous System
Neuroinflammation Field Grapples With Complexity at Keystone Symposia Nature Versus Nurture: What Gives Microglia Their Identity? Microglia in Disease: Innocent Bystanders, or Agents of Destruction? United in Confusion: TREM2 Puzzles Researchers in Taos C
FTLD Gene Bad Actor in Many TDP-43 Proteinopathies
A TMEM106B variant widely influences the formation of TDP-43 inclusions, even in people without noticeable signs of neurodegeneration.
Innovate, Then Stagnate? Brain Banks Improve Access But Are Now in Peril
Researchers strongly agree that brain banks are indispensable for important discoveries in neurodegenerative disease, but funding shortfalls now threaten to stall the pace of progress.
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