In Down's Syndrome, Blood P-Tau217 Detects Plaques and Tangles
In young adults with Down’s, plasma phospho-tau217 correlated with amyloid and tau PET positivity. With great accuracy.
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Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
The same endothelial cell response is found in various models of brain disease.
Potent TREM2 Antibody Stirs Microglia to Prune Plaques in Mice
A tetravalent IgG1 prompts TREM2 to cluster, boosting the receptor’s activation 100-fold. Treated mice had fewer plaques, better memories.
LRRK2 Variants Keep α-Synuclein from Forming Tetramers
The Parkinson’s-related proteins promoted pathological hyperphosphorylation of α-synuclein.
Blood Metabolome Predicts 23 Diseases, Including Dementia
Analysis of 168 metabolites in one blood sample foretold 10-year risk of developing common disorders.
Forced Into Fat-Burning Mode, Microglia Gobble Up Plaques, Protect Neurons
Blocking glycolysis triggers microglia to crank up lipid metabolism, boosting ATP production and improving phagocytosis. In Alzheimer’s disease, the opposite happens.
In TRAILBLAZER, Plasma GFAP Falls, but NfL Continues to Rise
While GFAP seems a sensitive biomarker of Aβ plaque removal, NfL might respond more slowly.
SYK It To ’Em: Kinase Enables Microglia to Clear Plaques
Sans SYK, mice struggle to mobilize disease-associated microglia or reign in amyloid or myelin fragments.
Gantenerumab Falls Short in Phase 3
The antibody removed less plaque than expected and did not slow cognitive decline, according to top-line data. Detailed data to come at CTAD.
Finally, a Biomarker to Distinguish Primary Tauopathies?
In two primary tauopathies, fragments containing tau’s microtubule-binding region drop in the CSF as they accumulate in the brain.
In Small Trial, Gene Therapy Spurs ApoE2 Production
ApoE2 was detected in cerebrospinal fluid of ApoE4 carriers with Alzheimer’s disease who received a virus expressing the protective allele.
Soluble Oligomer Assay Rivals Other Biomarkers in Detecting Preclinical AD
The assay captures α-sheet structure. It detected AD with 99 percent accuracy, including among healthy people who later became cognitively impaired.
In AD, CSF Immune Cells Hint at Mounting Mayhem in the Brain
CSF monocytes increasingly crank out the chemokine CXCL16, while T cells up its receptor, CXCR6. The same cross-talk unfolded among microglia and T cells around plaques.
Does Double-Stranded RNA From Jumping Genes Mediate Tau Toxicity?
In fly tauopathy model, dsRNA triggers inflammation and neuron death. In Alzheimer’s, dsRNA accumulates in the brain.
Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
Brain-derived forms of tau distinguished people with Alzheimer's from those with other neurodegenerative diseases.
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