SYK It To ’Em: Kinase Enables Microglia to Clear Plaques
Sans SYK, mice struggle to mobilize disease-associated microglia or reign in amyloid or myelin fragments.
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Gantenerumab Falls Short in Phase 3
The antibody removed less plaque than expected and did not slow cognitive decline, according to top-line data. Detailed data to come at CTAD.
Finally, a Biomarker to Distinguish Primary Tauopathies?
In two primary tauopathies, fragments containing tau’s microtubule-binding region drop in the CSF as they accumulate in the brain.
In Small Trial, Gene Therapy Spurs ApoE2 Production
ApoE2 was detected in cerebrospinal fluid of ApoE4 carriers with Alzheimer’s disease who received a virus expressing the protective allele.
Soluble Oligomer Assay Rivals Other Biomarkers in Detecting Preclinical AD
The assay captures α-sheet structure. It detected AD with 99 percent accuracy, including among healthy people who later became cognitively impaired.
In AD, CSF Immune Cells Hint at Mounting Mayhem in the Brain
CSF monocytes increasingly crank out the chemokine CXCL16, while T cells up its receptor, CXCR6. The same cross-talk unfolded among microglia and T cells around plaques.
Does Double-Stranded RNA From Jumping Genes Mediate Tau Toxicity?
In fly tauopathy model, dsRNA triggers inflammation and neuron death. In Alzheimer’s, dsRNA accumulates in the brain.
Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
Brain-derived forms of tau distinguished people with Alzheimer's from those with other neurodegenerative diseases.
When SORL1 Dimerizes in Endosomes, Retromers Recycle APP Faster
SORL1 may form polymers that bind and stabilize the retromer, facilitating the recycling of APP and other substrates.
Flipping the Script: Could Myelin Degeneration Drive Amyloidosis?
Myelin breakdown in the Alzheimer’s brain is thought to be a consequence of plaques, but a new study in mice suggests it may be a cause.
New Knock-In Mice Rapidly Accumulate Amyloid Plaques
The APP/PS1 double knock-ins begin to deposit amyloid in the brain by 3 months of age.
Those Declining Dementia Rates? It's Not the Plaques and Tangles
Across a three-decade span, there was no difference in amyloid pathology, but younger cohorts had healthier cerebrovasculature.
Does Neural Activity Drive DNA Repair?
In mice, the neuronal transcription factor NPAS4 recruits DNA repair machinery to active promoters; without it, double-strand DNA breaks accumulate.
Exercise May Not Keep People Sharp After All, Meta-Analysis Says
Authors say the evidence that physical activity improves cognition in healthy people is inconclusive. Others disagree.
Hi-Res Spatial Proteomics Uncovers Aspects of Alzheimer’s Disease Pathology
Multiplex analyses spy a new microglial subtype that surrounds Aβ plaques, and a type of neuron resilient to neurofibrillary tangles.
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