Complement: AD Friend or Foe? New Work Tips Balance to Former
When told what to kill, the complement system deftly deals the final blows...
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Revise Mechanism for Alzheimer's Drug? Acetylcholine Increased in Earliest Stage of Disease
Drugs called cholinesterase inhibitors have shown modest benefits for patients with mild to moderate Alzheimer's. In the February Annals of Neurology, researchers led by Steven DeKosky challenge the prevailing theory of how these drugs work...
Parkinson Pathways Branch Out in Flies and Mice
The tiny fruit fly <em>Drosophila</em> has served researchers well to unravel the function of genes linked to neurodegeneration in Parkinson disease...
CryoEM Exposes Possible Achilles’ Heel in Aβ1-42 Fibrils
The Aβ42 peptide may self-aggregate to form fibers with a structure profoundly different from those made of its less pathogenic cousin Aβ40...
Schizophrenia Drugs Said to Raise Stroke Risk in Dementia Patients
The Reuters news agency reported today that Eli Lilly and Co. has notified doctors of a significant increase in the risk for stroke and death that it has observed in demented elderly patients...
Editor’s Dozen: 13 Top AD Trends in 2010
The first day of the year is a time for personal reflection...
The A2M Deletion, Revisited
Last year Deborah Blacker, Rudolph Tanzi and their colleagues reported finding a strong association between a deletion of exon 18 in the gene for α2 macroglobulin (A2M) and Alzheimer's disease...
Rotterdam Study Questions Links between Fat and Dementia Risk
In conflict with a number of recent studies, six-year data from the Rotterdam study of aging failed to show a link between dietary fat and risk of dementia. The results are reported in today’s Neurology...
Lean Mice Live Longer: Does Insulin in Fat Hasten Aging?
Those who can eat as much as they please without gaining avoirdupois may feel smug about a paper in tomorrow’s Science, which reports that mice that lack insulin receptors only in their fat tissue outlive their normal brethren by about 18 percent...
ABCA1 Links Cholesterol and ApoE, But It May Not Be a Risk Factor for AD
Independent labs report that the cholesterol transporter ABCA1 keeps brain ApoE levels high and saturated with cholesterol, but a third paper casts doubt on the link between the transporter and AD...
San Diego: HIV and AD—Save the Body, Lose the Mind?
Drug cocktails have transformed HIV infection from a deadly to a chronic disease, giving HIV carriers a new lease on life. But new long-term consequences...
Coaxing Longevity from Catalase
Mice live longer and show signs of delayed aging when they express the antioxidant enzyme...
Youth Group Promotes Alzheimer’s Research and Support for Elderly
A youth movement promotes awareness of Alzheimer’s disease and elder issues among high school and college students, as well as encourage young people to go into AD research...
Peer Pressure? "Pal" Leads APP Down Amyloid Path
A newly discovered lipid modification on the amyloid precursor protein may mark it for amyloidogenic processing...
‘Godfather of Tau’ Skip Binder Dies at 63
Known for his contributions to the fundamental understanding of the tau protein, Skip Binder leaves his mark on the Alzheimer's field.
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