Can a Sex Hormone Boost Cognition in Down’s Syndrome?
Gonadotrophin-releasing hormone improved memory in a mouse model of DS, and it nudged up test scores in a pilot trial. The key? Dosing in pulses.
ALL NEWS
6538 RESULTS
Sort By:
- Most Recent
- Most Commented
In Cultured Human Neurons, Aβ Spurs Synapse Growth
While the familial Swedish AD mutation spurred synaptic growth, BACE inhibition, or APP deletion, had the opposite effect.
In Mice, TREM2 Antibody Mobilizes Microglia, Yet Worsens Tangles
Activating the microglial receptor also left amyloid untouched, despite prompting microglia to surround plaques.
Sans TREM2, ApoE4 Drives Microgliosis and Atrophy in Tauopathy Model
Phospho-tau and tangles accumulated, microglia bloated with lipids, and the brain atrophied in these mice.
Sans Microglia, Mice Develop CAA and Die Young
5xFAD mice lacking microglia develop cerebral amyloid angiopathy and amass calcium deposits. Most die by 6 months old.
Ferried Into Brain, TREM2 Antibody Stirs Microglia
A transferrin receptor binding domain helps transport the antibody across the blood-brain barrier. In the brain, it roused microglia and boosted glucose metabolism.
Piezo1 Steers Microglia Toward Rigid Aβ Plaques
Without this mechanosensor, microglia slowly respond to plaques. In mice, a Piezo1 agonist bolstered plaque containment and lowered amyloid burden.
As Parkinson’s Progresses, Do Synuclein Fibrils Shape-Shift?
Conformers amplified from CSF of late-stage PD adopt distinct folds and trouble neurons.
Droplets in the Bucket? Introducing en Masse Single-Synapse RNA-Seq
A new method reveals distinct synaptic states, some tied to amyloidosis, that were not seen in prior nuclear transcriptomic data.
Somatic Mutations Accrue in Alzheimer's Neurons
Excitatory neurons from people who died with Alzheimer’s disease carried more mutations than did neurons from healthy controls. Do such variants contribute to the demise of neurons?
Neuron-Specific Retromer Identified—Does It Stave Off Alzheimer’s?
When this retromer faltered in mice, Aβ levels rose in the brain and synaptic signaling waned in the transentorhinal cortex. General retromer loss in hippocampal neurons evoked dystrophic microglia similar to those seen in AD.
When Perivascular Macrophages Spew SPP1, Microglia Eat Synapses
In mice, oligomeric Aβ causes these macrophages to produce SPP1. Knocking out this pro-inflammatory cytokine quiets microglia and protects synapses.
Higher-Resolution Spatial Transcriptomics Maps Mayhem Near Plaques
Microglia within 10 micrometers of Aβ plaques expressed a disease-associated signature. Astrocytes rubbernecked from a bit farther away.
Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
Live imaging of mouse brain reveals that microglia quickly engulf cell bodies while astrocytes dispose of the neuron’s more distal reaches. The cleanup crew tires with age.
Brain Endothelial Cells Are Diverse, Perturbed by Amyloid
Single-nucleus RNA-Seq of human brain finds regional differences in endothelial cell subtypes. Transcriptomes change in the presence of plaque or vascular amyloid.
Current Filters
No filters selected