Mutant FUS Jams Axons, Blocking a Deacetylase May Help
In motor neurons carrying familial ALS FUS mutations, axonal transport of mitochondria stalls. HDAC6 inhibitors get traffic flowing again.
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For Synapses, Are Aβ Oligomers a No-Go?
The peptides may activate Nogo receptor signaling to block assembly of new synapses and compromise learning.
Scientists Unleash CRISPR on RNA
By harnessing a CRISPR-Cas nuclease that targets RNA, scientists have developed a way to edit transcripts, paving the way for RNA editing in mammalian cells.
Can Biomarker Data Predict Individual Risk for Alzheimer’s?
Researchers debut a statistical model that uses MRI, CSF, and demographic data to compute a cognitively impaired person’s risk for progressing to dementia.
Estimates of RNA Decay Hint at Destabilization in Alzheimer’s Brains
Using a new algorithm that measures mRNA decay rates more accurately than before, scientists claim that two RNA-binding proteins and four miRNAs determine the stability of mRNAs in the brain. Loss of RBFOX1 may destabilize synaptic protein mRNAs in Alzheimer’s disease.
FTD Variant Alters Chromatin, Boosts Expression of TMEM106b
A single-nucleotide polymorphism near the TMEM106b locus boosts expression of the gene, which is linked to frontotemporal dementia.
Gene Expression Map of Human Body Gives Value to Variants
In a massive project analyzing gene expression patterns among 44 human tissues from 449 people, researchers correlated genetic variation with region-specific transcriptomes.
Hippocampal Storms Leave Lasting Marks
Seizures in AD mice lead to cognitive changes via epigenetic suppression of calbindin-D28k.
ALS Kin Have More Neuropsychiatric Disease
Relatives of patients who have ALS are more likely to live with neuropsychiatric diseases such as schizophrenia, obsessive-compulsive disorder, and alcoholism.
Microbiota from Wild Mice Protect Lab Mice from Disease
Intestinal flora helps fight infection, inflammation, and cancer. What could this mean for neurodegeneration?
Changing With the Times: Disease Stage Alters TREM2 Effect on Tau
TREM2 accelerates neurodegeneration in one tauopathy model, but reduces tau pathology in another. Whether the microglial protein is good or bad may depend on stage of disease.
CRISPR Reveals New Suppressors of α-Synuclein Toxicity
New CRISPR screen flags dozens of genes that suppress toxicity of the Parkinson’s protein. Tweaking multiple genes strengthened the protection.
Lymphatic Vessels Found in Human Brain
Using modified MRI protocols, researchers were able to visualize these vessels in the dura mater of living people. The discovery challenges conventional wisdom.
Semagacestat, a Pseudo γ-Secretase Inhibitor?
Researchers claim this failed drug allows Aβ to accumulate inside cells, while small peptides cleaved from the C-terminal end of APP become trapped in membranes.
Artificial Human Blood Vessels: A Model for Cerebral Amyloid Angiopathy?
Human endothelial cells, smooth muscle cells, and astrocytes combine to form a vessel that ferries away Aβ, particularly Aβ42.
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