Pseudotime Simulates Disease Progression from Case-Control RNA-Seq
Aligning single-cell gene expression in “pseudotime” models longitudinal change. It explores how healthy cells become sick during Alzheimer's.
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Oligodendrocytes Pump Out Aβ42, Worsening Plaques and Synaptotoxicity
Three new papers report these myelin-producing cells contribute up to a third of plaque Aβ in transgenic mice.
Four Immunotherapies Now Banish Amyloid From the Brain
New data from gantenerumab and N3pG confirm that high-dose antibodies clear plaque dramatically, with manageable side effects. How will the aging brain respond?
Rising Leqembi Prescriptions Are Straining Clinic Capacity
With several thousand people across the U.S. on the drug, wait times are long, and clinics are hiring. How to meet growing demand?
Don’t Name It: Glial States Confound Easy Labels
By consensus, leaders in the astrocyte and microglia fields recommend that investigators eschew names in favor of detailed descriptions of reactive glia, with a focus on functional changes.
‘MGWAS’ Ties Brain Metabolites to Alzheimer’s, Parkinson’s, More
Lipids, amino acids, carbohydrates, and other molecules in the CNS linked to genetic variants, some of which upped the risk for neurodegenerative disease.
Can Anna Karenina Help Scientists Find Proteins That Cause Alzheimer’s?
A Tolstoy-inspired method identifies AD variants that exert similar effects, pinpointing causal AD proteins—six known, plus a new one, RET.
Neuronal Activity Ups Mitochondrial Transcription, Rallying Energy Reserves
With age, this coupling erodes, making synapses sluggish. Rekindling it lessens synaptic deficits and memory loss in old mice.
When Faced with Amyloidosis, Human Transplants Die by Necroptosis
In mice, the long noncoding RNA MEG3 mediated the death of human neurons, which accumulated tau tangles.
Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
By tracking how mutations influence the incorporation of monomers, scientists pinpoint which residues shape tau fibrils.
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
In AD mouse models, replacing ApoE3 with ApoE3Ch preserves memory.
Conference Coverage: IPSEN Foundation
ARF Scientific Advisor David Holtzman, of Washington University, St. Louis, Missouri, sent us this report from the IPSEN Foundation conference "Immunization against Alzheimer's and other Neurodegenerative Diseases," held on 13 March in Paris, France...
Plaque Clearance, Antibody Isotype Are Key for Passive Aβ Immunization
Plaque clearance is a better correlate of neural protection via passive amyloid immunization than soluble amyloid-beta (Aβ) clearance, and this protection is based on Fc receptor-mediated Aβ phagocytosis...
A Kinder, Gentler Alzheimer's Vaccine?
Thomas Wisniewski, Einar Sigurdsson, and colleagues at New York University report that they have prevented amyloid-β deposition by immunizing a mouse model of Alzheimer's disease with a nontoxic Aβ homologue...
Tubulin Chaperone Found to Cause Rare Motor Neuron Degeneration, and More
Crumbling microtubules, those slender filaments that aid a variety of cellular processes from cell division to vesicle trafficking, could lead to motor neuron disease...
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