Peter Davies, Beloved Giant of Alzheimer’s Disease Research, Dies at 72
In a career spanning four decades, Davies spearheaded the cholinergic hypothesis, unlocked secrets of tau, and readily shared antibodies in the field.
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CPTX—A Synaptic “Glue” Restores Memory in Alzheimer’s Model
The designer chimera stabilizes synapses in various mouse models of neurodegenerative disease.
IFITM3 Forges Link Between Neuroinflammation and Aβ Production
The antiviral protein enhances γ-secretase processing of APP. More of it is present in Alzheimer’s disease.
Global Genetics Symposium Starts Today
Three weeks of on-demand seminars to culminate in live Q&A.
First Primate Model of Familial AD: Marmosets with Presenilin Mutation
Three young monkeys missing exon 9 of presenilin 1 seem to have an elevated Aβ42/40 ratio. It remains to be seen if they will develop plaques and tangles as they age.
Molecular Structure of LRRK2 Gives Clues to Parkinson’s
The first high-resolution look at LRRK2 implies that pathogenic mutations increase binding to microtubules by biasing the kinase domain toward a closed, active conformation.
Does Second X Chromosome Boost Women’s Resilience Against Alzheimer’s?
In female mice it’s the other X chromosome, not lack of a Y, that extends life and preserves memory in the face of amyloidosis. A histone demethylase gene partly explains this. It protects people, too.
Does Phosphorylation of Presenilin 1 Drive Microglial Migration, Aβ Clearance?
In mice with defective PS1 phosphorylation, microglial autophagy falters, exacerbating Aβ burden.
With Tau in Synapses, NO Neurovascular Coupling
Dendritic tau suppresses production of nitric oxide, which prevents blood vessels from dilating in response to neural activity.
Tunneling Nanotubes—How Pericytes Control Blood Flow
In the mouse retina, these tender threads connect pericytes on nearby capillaries. They enable cells to coordinate constriction and dilation of blood vessels in response to neuronal activity.
Can Loss of a Single Protein Domain Cause ‘Alzheimer’s’ in Mice?
Without the WD domain of Atg16L1, required for a newly discovered type of endocytosis, old mice develop hallmark pathologies of AD.
Klotho VS Variant Preserves Memory by Preventing Tangles
Carriers accumulate fewer tangles than noncarriers for a given amount of amyloid, explaining how the gene variant may lower a person’s Alzheimer’s risk.
At AAIC, Hints of Target Engagement for Some Drug Candidates
Early data suggest that CT1812 and AL001 shift biomarker levels in Alzheimer’s disease and frontotemporal dementia, respectively. BI 425809 fails to improve cognition.
Umibecestat-Driven Cognitive Decline Is Reversible
Subtle memory deficits resolved after volunteers stopped taking the Novartis BACE inhibitor.
Seeing into the Human Synapse: New Tools Illuminate Alzheimer’s Hot Spot
New synaptic profiling and imaging techniques are enabling scientists to zero in on synaptic proteins, including phospho-tau, that make the difference between clinical Alzheimer’s and resilience.
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