Proteomics Dates Endosomal, Synaptic Changes to Preclinical AD
In postmortem brain, proteins involved in all manner of vesicular functions waxed or waned with increasing phases of disease, starting years prior to symptoms.
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Microglia Build Plaques to Protect the Brain
Instead of chewing up and disposing of the amyloid they ingest, microglia appear to compact it, then spit it back out as dense-core plaque.
In Pilot Study, Electric Therapy Improves Memory
Sending low-intensity, gamma frequency electric current through the brain boosted short-term memory, perhaps by increasing cholinergic transmission.
More Data on Herpes and Alzheimer’s Disease
Herpes infection upped risk in ApoE4 carriers, damaged brain tissue, and correlated with neurodegeneration markers in the CSF.
Tau, Speckle Wrecker, Disrupts the Nuclear Home
Disruption of the membraneless organelles may explain toxicity of tau aggregates.
Does Re-entering the Cell Cycle Help Neurons Survive?
In cell culture, neurons with the strongest expression of cell-cycle proteins survived best in the presence of Aβ oligomers.
Does Synchronizing Brain Waves Bring Harmony?
In early stage trials, light and sound promoted neuronal communication, calmed immune cells, and slowed brain atrophy, but cognitive benefit remains unclear.
Advisory Committee Again Urges FDA to Vote No on Aducanumab
After news on “new data” they won’t see, three committee members argue against approval.
Squelching ApoE in Astrocytes of Tau-Ravaged Mice Dampens Degeneration
In therapy-like paradigm, suppressing ApoE4 in astrocytes toned down tauopathy. This assuaged microglia, neurodegeneration, and revived nest-building.
What BACE Hits: New Substrates Create New Headaches
New research implicates IL-6 signaling and even Aβ42 itself as BACE targets, complicating efforts to resurrect BACE inhibitors at a low dose.
Drop of Hope? No Cognitive Worsening on BACE Inhibitor
Data from Phase 3 trials of elenbecestat show no harm to cognition, leaving open a chance that the drugs could be used safely in the future.
Dysfunctional Lysosomes Cause Ferroptosis in Neurons
The first whole-genome manipulation of protein expression in neurons by CRISPR reveals a deadly chain of events. Bad processing by lysosomes leads to build-up of lipids and iron. Oxidative stress revs up. Neurons die by ferroptosis.
TREM2 Variants and CSF sTREM2 Levels Differ by Race
African Americans are likelier than non-Hispanic Caucasians to carry low-expression TREM2 variants, and less likely to carry a high-expression variant. As a result, they have less soluble TREM2 in their cerebrospinal fluid.
Clinical Trials in COVID Era: How To Keep Moving Forward
By shifting to home nursing and telemedicine, clinical researchers kept inching ahead during lockdowns.
COVID-19 Worsens Neurological Problems, Delirium
At AD/PD 2021, clinicians discussed neurological symptoms and brain tissue damage in older people who died from COVID-19.
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