Paper Alert: GWAS Hits Clusterin, CR1, PICALM Formally Published
Yesterday, Nature Genetics online released full reports of the two largest genomewide association studies of sporadic Alzheimer disease performed to date..
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Yesterday, Nature Genetics online released full reports of the two largest genomewide association studies of sporadic Alzheimer disease performed to date..
The normal role of Aβ is intimately tied up with synaptic electrophysiology. On the flip side, disturbances in the regulatory interplay between synaptic activity and AβP processing could yield clues to a better explanation of how...
A mitochondrial matrix protease, which degrades short targeting sequences left over after protein import, can also...
Don’t let the name fool you; there’s nothing minor about microRNAs...
Statin supporters got a boost last week when researchers reported that...
A cat might be the last thing a sickly AD mouse needs, particularly if it is CatB...
Scientists in Germany have created a membrane-tethered version of a β-secretase inhibitor...
One of the shortcomings of most mouse models of Alzheimer disease is that they fail to recapitulate the rampant neurodegeneration that is seen in humans...
Two studies revive the notion that it might be possible, quite literally, to catch a whiff of neurodegenerative disease before the body and mind slip away for good...
At AAIC 2013, researchers present the latest genetic risk factors for Alzheimer's disease.
Neuroscientists focus much attention on long-lasting aggregates such as tangles and plaques, but they would do well to study transient gobs like stress granules also...
If another small, hopeful trial is to be believed, pooled antibody treatment has the potential to stave off dementia...
A failure to dispose of underperforming mitochondria may underlie the complex degenerative disorder known as multisystem proteinopathy...
Everyone knows that omega-3 polyunsaturated fatty acids (PUFAs) are good for you (eat your fish!), but no one really knows why...
The carving up of the APP by the successive action of β- and γ-secretases liberates Aβ, but also yields a small intracellular fragment, AICD...