Tau Filaments Found Tethered Inside Alzheimer's Brain Exosomes
Bound up in vesicles extracted from Alzheimer's brain, tau filaments adopt their characteristic back-to-back C-shape. A mystery molecule is involved in tying them down.
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Amyloid Atlas Showcases 261 Structures, and Counting
The public database includes information about the structure, polarity, and stability of both pathogenic and functional amyloid folds.
Are Hormones to Blame for High Tau in Women?
One study links early menopause to tangles in early AD, another finds a sex difference in the brain's stress response. Could hormones fuel women’s higher risk of dementia?
Whole Genome Analysis Nets New Lewy Body Dementia Gene
A deletion in the gene for a lysosomal ion channel popped out of a genomic analysis of LBD risk. So did rare structural variants in other FTD and ALS genes.
Long COVID and Dementia: The Link Is Still Elusive
While memory problems plague some people with lingering COVID symptoms, researchers do not yet understand what is going wrong in their brains.
In Tired Mice, TREM2 Addles Microglia
In sleep-deprived mice, TREM2 signaling activated microglia in a dysfunctional way, hobbling their endolysosomes and keeping them from digesting Aβ plaques.
And Then There Were Three: Donanemab Phase 3 Trial Positive
The antibody slowed decline by 35 percent, met secondary endpoints, will likely be approved. Major question: How to avoid severe ARIA.
New Arrows Aimed at Tau: Single-Domain Antibody, Peptibody, Vaccine
Scientists devised fresh approaches for curbing tau tangles that might better reach the protein inside cells, or target several pathologies at once.
Microglia Conflicted: To Help, or to Hinder, Tau’s March Across the Brain?
Data from TRIAD cohort cast activated microglia, egged on by ApoE4, as harbingers of tau pathology and neurodegeneration. Data from BioFinder hint that other microglia restrain these processes.
Dysregulated Lipid Metabolism Comes to the Fore at AD/PD
In Alzheimer’s, Parkinson’s, and Lewy body dementia, phospholipid and cholesterol homeostasis are disrupted early on. Scientists are bringing new methods to bear on the problem.
Paper Alert: Tau Antisense Oligonucleotide BIIB080 Hits Its Target
Safety and cerebrospinal fluid tau data from the six-month Phase 1 trial are now published.
By Unleashing Microglial cGAS, Tau STINGs Neurons
cGAS and STING initiate a type I interferon response, which weakens neurons’ resilience to tau pathology.
FDA Grants Accelerated Approval for Tofersen
The antisense oligonucleotide targets extremely rare variants of the superoxide dismutase 1 gene.
With Microglia, It Takes a Village to Connect the Dots
Scientists showed how pooling microglia from different donors, then putting them through cutting-edge analyses, can link genetic variation to functional change.
From Phagocytosis to Exophagy: Microglia's Digestive Tract Dissected
At AD/PD, scientists zeroed in on endolysosomal mechanisms in microglia that may contribute to neurodegenerative disease. Blending omics with cellular studies leads them from genes and function.
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