Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| ALPHA-1062 | GLN-1062 , Memogain |
Alzheimer's Disease (Phase 3) | Alpha Cognition, Galantos Pharma | Cholinergic System | Small Molecule | |
| Alpha-Tocopherol | Vitamin E | Alzheimer's Disease (Phase 3) | Other | Supplement, Dietary | ||
| ALZ-801 | valiltramiprosate, NRM-8499, homotaurine prodrug, 3-APS |
Alzheimer's Disease (Phase 3) | Alzheon Inc. | Amyloid-Related | Small Molecule | |
| ALZT-OP1 | Cromolyn sodium, Intal, Ibuprofen |
Alzheimer's Disease (Phase 3) | AZTherapies, Inc. | Amyloid-Related, Inflammation | Combination, Small Molecule | |
| AR1001 | Alzheimer's Disease (Phase 3) | Aribio Co., Ltd. | Other | Small Molecule | ||
| Aripiprazole | Abilify, BMS-337039 |
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) | Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Bezisterim | NE3107, HE3286 |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 1/2) | BioVie Pharma | Inflammation, Other | Small Molecule | |
| Citalopram | escitalopram, Celexa, Lexapro , Cipralex |
Alzheimer's Disease (Phase 3), Preclinical Alzheimer's Disease (Inactive) | Other Neurotransmitters | Small Molecule | Depression, generalized anxiety disorder | |
| Continuous Positive Airway Pressure | CPAP | Alzheimer's Disease (Phase 3) | Unknown | Procedural Intervention | Sleep Apnea in US | |
| Deep Brain Stimulation-fornix | DBS-f | Alzheimer's Disease (Phase 3) | Functional Neuromodulation Ltd | Unknown | Procedural Intervention | |
| Guanfacine | Intuniv, SPD503, Afken, Estulic, Tenex |
Alzheimer's Disease (Phase 3) | Other Neurotransmitters | Small Molecule | Attention-deficit hyperactivity disorder, hypertension | |
| GV1001 | RIAVAXTM, Tertomotide | Alzheimer's Disease (Phase 3) | GemVax & KAEL Bio | Other | Immunotherapy (active) | Pancreatic cancer (Korea) |
| HMTM | LMTM, LMTX, LMT-X, TRx0237, Tau aggregation inhibitor (TAI), Methylene Blue |
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) | TauRx Therapeutics Ltd | Tau | Small Molecule | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
| KarXT | xanomeline-trospium, BMS-986510, CobenfyTM |
Alzheimer's Disease (Phase 3) | Bristol-Myers Squibb, Karuna Therapeutics | Cholinergic System | Combination, Small Molecule | Schizophrenia |
| Lumateperone | ITI-007 | Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) | Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. | Other Neurotransmitters | Small Molecule | |
| Masitinib | Masivet, Kinavet, AB1010, Masitinib mesylate |
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) | AB Science | Other | Small Molecule | |
| Masupirdine | SUVN-502 | Alzheimer's Disease (Phase 3) | Suven Life Sciences Ltd | Other Neurotransmitters | Small Molecule | |
| Mirtazapine | Remeron, esmirtazapine, Org 50081 |
Alzheimer's Disease (Phase 3) | Other Neurotransmitters | Small Molecule | ||
| Nabilone | Cesamet | Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Bausch Health Companies Inc. | Other Neurotransmitters | Small Molecule | Nausea associated with cancer chemotherapy (US and other countries); pain spasticity in multiple sclerosis (Canada and other countries). |
| Pioglitazone | AD4833, Actos®, Glustin™, Piozone® |
Mild Cognitive Impairment (Phase 3) | Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. | Inflammation, Other | Small Molecule | Type 2 diabetes mellitus |
| Remternetug | LY3372993, N3pG-Abeta mAb |
Alzheimer's Disease (Phase 3) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | |
| Semaglutide | Ozempic, Wegovy, Rybelsus |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Type 2 Diabetes, Obesity, Protection against myocardial infarction and stroke |
| Sensory Stimulation Systems | GENUS, Gamma entrainment using sensory stimuli, GammaSense Stimulation |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Not Regulated), Down's Syndrome (Not Regulated) | Cognito Therapeutics, Inc. | Amyloid-Related, Inflammation, Other | Combination, Procedural Intervention | |
| Trazodone | Trazodone hydrochloride, Oleptro, Desyrel |
Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2/3) | Other Neurotransmitters | Small Molecule | Depression | |
| Tricaprilin | AC-1204 , Caprylic triglyceride, AC-SD-03, CER-000, AC-OLE-O1-VA |
Alzheimer's Disease (Phase 3) | Cerecin Pte. Ltd. | Other | Supplement, Dietary, Other | None |