Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| AAB-003 | PF-05236812 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
| ABBV-916 | N3pG-Abeta mAb | Alzheimer's Disease (Phase 2) | Amyloid-Related | Immunotherapy (passive) | ||
| ABvac40 | Alzheimer's Disease (Phase 2) | Araclon Biotech | Amyloid-Related | Immunotherapy (active) | ||
| ACI-24.060 | ACI-24, Pal1-15 acetate salt |
Alzheimer's Disease (Phase 2), Down's Syndrome (Phase 2) | AC Immune SA, Takeda Pharmaceutical Company | Amyloid-Related | Immunotherapy (active) | |
| Acitretin | Soriatane , Neotigason, RO 101670 |
Alzheimer's Disease (Phase 2) | Actavis, Allergan plc | Amyloid-Related | Small Molecule | Psoriasis in US |
| Aduhelm | Aducanumab, BIIB037 |
Alzheimer's Disease (Approved) | Biogen, Neurimmune | Amyloid-Related | Immunotherapy (passive) | |
| Affitope AD02 | Alzheimer's Disease (Discontinued) | AFFiRiS AG | Amyloid-Related | Immunotherapy (active) | ||
| ALIA-1758 | Alzheimer's Disease (Phase 1) | AbbVie, Aliada Therapeutics | Amyloid-Related | Immunotherapy (passive) | ||
| ALN-APP | Alzheimer's Disease (Phase 1) | Alnylam Pharmaceuticals, Inc., Regeneron Pharmaceuticals Inc. | Amyloid-Related | DNA/RNA-based | ||
| ALX-001 | BMS-984923 | Alzheimer's Disease (Phase 1) | Allyx Therapeutics, Inc. | Amyloid-Related, Other Neurotransmitters | Small Molecule | |
| ALZ-101 | Alzheimer's Disease (Phase 1) | Alzinova AB | Amyloid-Related | Immunotherapy (active) | ||
| ALZ-801 | valiltramiprosate, NRM-8499, homotaurine prodrug, 3-APS |
Alzheimer's Disease (Phase 3) | Alzheon Inc. | Amyloid-Related | Small Molecule | |
| Alzhemed™ | Vivimind™, Tramiprosate, NC-531, homotaurine, 3-APS |
Alzheimer's Disease (Discontinued) | Neurochem, Inc. | Amyloid-Related | Supplement, Dietary | None |
| ALZT-OP1 | Cromolyn sodium, Intal, Ibuprofen |
Alzheimer's Disease (Phase 3) | AZTherapies, Inc. | Amyloid-Related, Inflammation | Combination, Small Molecule | |
| Amilomotide | CAD106 | Alzheimer's Disease (Inactive) | Novartis Pharmaceuticals Corporation | Amyloid-Related | Immunotherapy (active) | None |
| AN-1792 | AIP 001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (active) | None |
| Atabecestat | JNJ-54861911 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Janssen, Shionogi Pharma | Amyloid-Related | Small Molecule | |
| AV-1959D | AV-1959 | Alzheimer's Disease (Phase 1) | Amyloid-Related | Immunotherapy (active) | ||
| Avagacestat | BMS-708163 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Amyloid-Related | Small Molecule | |
| Azeliragon | PF-04494700, TTP488 |
Alzheimer's Disease (Discontinued) | Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC | Amyloid-Related, Inflammation | Small Molecule | |
| Bapineuzumab | AAB-001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
| Bexarotene | Targretin® | Alzheimer's Disease (Phase 2) | Ligand Pharmaceuticals, Inc., ReXceptor Inc. | Amyloid-Related, Unknown | Small Molecule | Cutaneous T-cell Lymphoma in US |
| BI 1181181 | VTP 37948, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Boehringer Ingelheim, Vitae Pharmaceuticals | Amyloid-Related | Small Molecule | |
| Buntanetap | Posiphen, ANVS-401, Posiphen tartrate |
Alzheimer's Disease (Phase 2/3), Parkinson's Disease (Phase 3) | Annovis Bio | Amyloid-Related, alpha-synuclein | Small Molecule | |
| CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
| Clioquinol | iodochlorhydroxyquin, PBT-1 |
Alzheimer's Disease (Discontinued) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| CpG 1018® | CpG oligodeoxynucleotides, CpG ODN |
Alzheimer's Disease (Phase 1) | Dynavax Technologies | Amyloid-Related, Inflammation | Immunotherapy (active), DNA/RNA-based | |
| Crenezumab | MABT5102A , RG7412 |
Alzheimer's Disease (Discontinued) | AC Immune SA, Genentech, Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | None |
| CS6253 | Cogpep™, CS-6253 |
Alzheimer's Disease (Phase 1) | Artery Therapeutics, Inc. | Amyloid-Related, Cholesterol | Small Molecule | |
| CT1812 | Elayta | Alzheimer's Disease (Phase 2) | Cognition Therapeutics Inc. | Amyloid-Related | Small Molecule | |
| DNL919 | TAK-920, ATV:TREM2 |
Alzheimer's Disease (Discontinued) | Denali Therapeutics Inc., Takeda Pharmaceutical Company | Amyloid-Related, Inflammation | Immunotherapy (passive) | |
| Donanemab | N3pG-Aβ Monoclonal Antibody, LY3002813, Kisunla |
Alzheimer's Disease (Approved) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | |
| Efavirenz | Efavirenz | Alzheimer's Disease (Phase 1) | Amyloid-Related, Tau, Cholesterol | Small Molecule | HIV infection | |
| Elenbecestat | E2609, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Biogen, Eisai Co., Ltd. | Amyloid-Related | Small Molecule | |
| ELND005 | AZD-103, Scyllo-inositol, cyclohexane-1,2,3,4,5,6-hexol |
Alzheimer's Disease (Inactive) | Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. | Amyloid-Related | Small Molecule | None |
| Epigallocatechin Gallate (EGCG) | Sunphenon EGCg | Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) | Taiyo International | Amyloid-Related, Inflammation, Other | Supplement, Dietary | |
| EVP-0962 | EVP 0015962 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | FORUM Pharmaceuticals Inc. | Amyloid-Related | Small Molecule | |
| Flurizan™ | tarenflurbil , r-flurbiprofen, MPC-7869 |
Alzheimer's Disease (Discontinued) | Myriad Genetics & Laboratories | Amyloid-Related | Small Molecule | None |
| Focused Ultrasound – Blood-Brain Barrier | FUS-BBB, MRgFUS, MRI-Guided Focused Ultrasound, FUS+MB |
Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 1), Mild Cognitive Impairment (Phase 1), Parkinson's Disease (Phase 1) | Amyloid-Related, Other | Procedural Intervention | ||
| Gammagard® | Intravenous Immunoglobulin, IVIg |
Alzheimer's Disease (Discontinued) | Baxter Healthcare | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency conditions |
| Gamunex | Intravenous Immunoglobulin, Human Albumin Combined With Flebogamma |
Alzheimer's Disease (Phase 2/3) | Grifols Biologicals Inc. | Amyloid-Related, Inflammation | Combination, Immunotherapy (passive) | Immunodeficiency, chronic inflammatory demyelinating neuropathy |
| Gantenerumab | RO4909832, RG1450, R1450 |
Alzheimer's Disease (Discontinued) | Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | |
| GSK933776 | Alzheimer's Disease (Inactive) | GlaxoSmithKline (GSK) | Amyloid-Related | Immunotherapy (passive) | ||
| GV-971 | sodium oligomannate, sodium oligo-mannurarate |
Alzheimer's Disease (Inactive) | Shanghai Green Valley Pharmaceuticals | Amyloid-Related, Inflammation | Small Molecule | |
| IBC-Ab002 | Alzheimer's Disease (Phase 1) | ImmunoBrain Checkpoint | Amyloid-Related, Inflammation, Other | Immunotherapy (passive) | ||
| Ibuprofen | Advil™, Nuprin™ , Motrin™ |
Alzheimer's Disease (Discontinued) | Amyloid-Related, Inflammation | Small Molecule | Pain and Fever | |
| Lanabecestat | AZD3293 , LY3314814, BACE inhibitor |
Alzheimer's Disease (Discontinued) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| Lenalidomide | Revlimid | Alzheimer's Disease (Phase 2) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | Multiple myeloma, lymphoma, myelodysplastic syndromes |
| Leqembi | Lecanemab-irmb, BAN2401, mAb158 |
Alzheimer's Disease (Approved) | BioArctic AB, Biogen, Eisai Co., Ltd. | Amyloid-Related | Immunotherapy (passive) | |
| Levetiracetam | Keppra | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) | UCB S.A. | Amyloid-Related, Other | Small Molecule | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
| Lu AF20513 | Alzheimer's Disease (Discontinued) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Amyloid-Related | Immunotherapy (active) | ||
| LX1001 | AAVrh.10-APOE2, AAVrh.10hAPOE2 |
Alzheimer's Disease (Phase 1) | Lexeo Therapeutics | Amyloid-Related | DNA/RNA-based | |
| LY2599666 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
| LY2886721 | BACE inhibitor | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| LY3202626 | BACE Inhibitor | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| MEDI1814 | Alzheimer's Disease (Phase 1) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
| MemorEM Transcranial Electromagnetic Treatment | TEMT | Alzheimer's Disease (Phase 1) | NeuroEM Therapeutics, Inc. | Amyloid-Related, Other | Procedural Intervention | |
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin, glulisine |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Supplement, Dietary | |
| Octagam®10% | Intravenous Immunoglobulin, NewGam |
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) | Octapharma | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency disorders |
| PBT2 | PBT-2 | Alzheimer's Disease (Inactive), Huntington's Disease (Inactive) | Alterity Therapeutics | Amyloid-Related, Metals | Small Molecule | |
| PF-06648671 | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | ||
| PF-06751979 | BACE inhibitor | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | |
| PMN310 | Alzheimer's Disease (Phase 1) | ProMIS Neurosciences, Inc. | Amyloid-Related | Immunotherapy (passive) | ||
| Ponezumab | PF-04360365 | Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) | Pfizer | Amyloid-Related | Immunotherapy (passive) | None |
| PRI-002 | Contraloid, contraloid acetate, RD2 |
Alzheimer's Disease (Phase 1) | Priavoid GmbH | Amyloid-Related | Small Molecule | |
| PRX012 | Alzheimer's Disease (Phase 1) | Prothena | Amyloid-Related | Immunotherapy (passive) | ||
| Remternetug | LY3372993, N3pG-Abeta mAb |
Alzheimer's Disease (Phase 3) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | |
| RG6289 | Alzheimer's Disease (Phase 1/2) | Hoffmann-La Roche | Amyloid-Related | Small Molecule | ||
| RG7129 | RO5508887, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Roche | Amyloid-Related | Small Molecule | |
| Sabirnetug | ACU-193 | Alzheimer's Disease (Phase 2/3) | Acumen Pharmaceuticals, Inc. | Amyloid-Related | Immunotherapy (passive) | |
| SAR228810 | Alzheimer's Disease (Discontinued) | Sanofi | Amyloid-Related | Immunotherapy (passive) | ||
| Semagacestat | LY450139 Dihydrate , hydroxylvaleryl monobenzocaprolactam |
Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | None |
| Sensory Stimulation Systems | GENUS, Gamma entrainment using sensory stimuli, GammaSense Stimulation |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Not Regulated), Down's Syndrome (Not Regulated) | Cognito Therapeutics, Inc. | Amyloid-Related, Inflammation, Other | Combination, Procedural Intervention | |
| SHR-1707 | Alzheimer's Disease (Phase 2) | Amyloid-Related | Immunotherapy (passive) | |||
| Simufilam | PTI-125, sumifilam |
Alzheimer's Disease (Phase 3) | Cassava Sciences | Amyloid-Related | Small Molecule | |
| Solanezumab | LY2062430 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | None |
| Thalidomide | Thalomid® | Alzheimer's Disease (Discontinued) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | |
| Trontinemab | RO7126209, RG6102 , Brain shuttle gantenerumab |
Alzheimer's Disease (Phase 1/2) | Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | |
| UB-311 | Alzheimer's Disease (Phase 2) | United Neuroscience, Vaxxinity | Amyloid-Related | Immunotherapy (active) | ||
| Umibecestat | CNP520, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Amgen, Inc., Novartis Pharmaceuticals Corporation | Amyloid-Related | Small Molecule | |
| Vanutide cridificar | ACC-001, PF-05236806 |
Alzheimer's Disease (Discontinued) | Janssen | Amyloid-Related | Immunotherapy (active) | None |
| Varoglutamstat | PQ912 | Alzheimer's Disease (Discontinued) | Probiodrug AG, Vivoryon Therapeutics N.V. | Amyloid-Related, Inflammation | Small Molecule | |
| Verubecestat | MK-8931, MK-8931-009 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Merck | Amyloid-Related | Small Molecule | |
| VG-3927 | Alzheimer's Disease (Phase 1) | Vigil Neuroscience, Inc. | Amyloid-Related, Inflammation | Small Molecule |