Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 5;43(3):333-44. PubMed.

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Comments

  1. Beautiful and elaborate work. It would be of interest to examine in detail whether LRP-dependent clearance affects parenchymal amyloidosis or amyloid angiopathy, and whether LRP-dependent clearance is more associated with clearance through the blood-brain barrier or through astrocytotic endocytosis/phagocytosis.

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