Donanemab Clinical Use Growing in U.S., Rejected in Europe
Donanemab prescriptions have been slow to ramp up, but demand is growing due an easier dosing schedule than for lecanemab.
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Plaque Removal Delays Onset of Familial Alzheimer’s Disease
Healthy people who carry an autosomal-dominant AD mutation halved their odds of developing symptoms when they took gantenerumab for eight years.
Filling in the Family Tree—AD, CTE Folds Spotted in Other Tauopathies
Core structures of protofilaments from more diseases prompt an update to the family tree of tau filaments.
Is Dementia Incidence Still Dropping? Birth Cohort Data Say Yes.
Dementia prevalence has come down nearly 3 percent per year for the last 40 years, with each successive birth cohort less likely to succumb.
Mobile Devices Track Brain Health in 23,000 People
In the largest study of its kind, volunteers took cognitive tests on their devices and had their app usage monitored. Baseline data flagged people with MCI.
Eat Well, Stay Trim—Your Brain Will Thank You Later
People who ate a healthy diet and carried less abdominal fat in midlife had better-working brains 20 years later, according to MRI scans.
ALS or Alzheimer’s? Blood Phospho-Tau Could Mean Either
P-tau181 and p-tau217 are AD biomarkers, but they are also found in blood and muscles of people with ALS.
Alzheimer’s Risk Variants Found in Diverse Populations
A large meta-analysis turns up 16 new loci.
After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods
Expression of TREM2, ApoE, and complement proteins correlated with extensive plaque clearance in response to Aβ immunotherapy.
Pretty in PINK1, Cryo-EM Reveals How Kinase Anchors to Mitochondria
Behold the first high-resolution structure of the human Parkinson’s-related kinase bound to mitochondrial membranes.
Confirmed: Women Accumulate Tangles Faster Than Do Men
Meta-analysis of six longitudinal studies finds that, among people who are amyloid-positive, tau PET signal rose faster in women.
In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
Inhibiting this receptor calmed reactive astrocytes and curbed their consumption of synapses in the hippocampus in a mouse amyloidosis model.
Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients
The largest single-cell RNA-Seq study of blood cells finds more sex-specific expression changes in PD than AD. The database is accessible online.
Fragments of Tau’s Microtubule Binding Region Mess with Synapses
In rats, antibodies to the MTBR domain and adjacent C-terminal regions spared synaptic function.
Can Autoimmunity Spark Alzheimer’s Disease?
Electronic health records show that various autoimmune disorders put people at higher risk for AD.
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