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Larry Sparks, of Alzheimer’s-Cholesterol Fame, Dies at 63
18
May 2013.
Alzheimer's disease researchers expressed sadness this week at the sudden death of Larry Sparks...
Skin Cancer Linked to Lower AD Risk—But Don't Hit the Beach Just Yet
17
May 2013.
Skin cancer, a common and typically curable malignancy, may carry a fringe benefit—protection from Alzheimer’s disease...
Study Finds Ways to Predict, Track Huntington’s Disease
17
May 2013.
Anticipating future clinical trials for Huntington’s disease, researchers are seeking sensitive measures that will predict onset and track progression...
Dementia Incidence Said to Drop as Public Health Improves
17
May 2013.
Are fewer people getting Alzheimer’s disease now than they did 20 years ago?...
Ubiquitin System Awry in Ataxia, Intellectual Disability
17
May 2013.
Two new papers this month shore up the connection between cell waste disposal and function of neurons...
Yueming Li and Lennart Mucke Win MetLife Foundation Award
15
May 2013.
Today, the MetLife Foundation honored Yueming Li and Lennart Mucke with its 2013 Awards for Medical Research in Alzheimer’s Disease...
Could Longevity Factor, Epilepsy Med, Treat AD One Day?
14
May 2013.
At a San Francisco conference addressing Alzheimer’s and related disorders, the agenda featured a diverse mix of topics—occasionally even from the same lab...
Paracrine Signal From BACE1-Clipped Neuregulin Rescues Myelin
13
May 2013.
As β-secretase inhibitors head into Alzheimer’s disease trials, researchers are paying close attention to what else BACE1 does besides snip amyloid-β from APP...
Endocytosis Pulls α-Secretase From Synapses
13
May 2013.
Scientists report that endocytosis whisks α-secretase away from the cell membrane in a process that seems regulated by neuronal activity...
Guidelines at Nature Aim to Stem Tide of Irreproducibility
10
May 2013.
It has become a complaint heard all too often—much academic research cannot be reproduced...
Therapeutic Approaches Target Deubiquitinase, Protein Turnover
10
May 2013.
This scientific meeting that drew some 150 researchers to San Francisco 15-17 April 2013 featured an unusually broad array of topics...
Paper Alert: Antisense Oligonucleotide Therapy Safe for ALS?
9
May 2013.
An oligonucleotide designed to tamp down an enzyme that causes amyotrophic lateral sclerosis seems safe...
Gammagard™ Misses Endpoints in Phase 3 Trial
8
May 2013.
Topline data yesterday showed that intravenous immunoglobulin (IVIG) therapy, known as Gammagard™, failed to meet primary endpoints of slowing cognitive and functional decline...
Criminal Minds: Explaining Lack of Empathy in Prison Psychopaths
8
May 2013.
People with psychopathic tendencies—who may constitute upwards of 15 percent of prison populations—poorly activate parts of the brain responsible for empathy...
Stem Cells Treat Epileptic Symptoms in Mice
8
May 2013.
Using stem cells to replace inhibitory neurons in the hippocampi of adult epileptic mice reduced hyperexcitability, seizures, and behavioral deficits...
Not Seeing Eye to Eye: Do Lenses Accumulate Aβ?
8
May 2013.
What if you could diagnose Alzheimer’s disease at an early stage by examining a person’s eyes?...
Do Microglia in the Hypothalamus Drive Aging?
3
May 2013.
Microglia have taken center stage in Alzheimer’s disease (AD) research recently...
Can Transferrin Antibodies Safely Open the Blood-Brain Barrier?
3
May 2013.
For decades scientists have sought a way to sneak large drugs across the blood-brain barrier...
ALS in Han Chinese: Different Race, Different Genetics?
3
May 2013.
Researchers using genomewide screens have identified two new loci for sporadic amyotrophic lateral sclerosis genes in the Han Chinese population...
Research Brief: New Mouse Line for Studying Upper Motor Neurons
3
May 2013.
In the study of ALS, lower motor neurons in the spine have received the lion's share of attention—but now there is a tool to focus on the role of upper motor neurons in the cortex...
Foundation Offers $100,000 for Sex Differences in Alzheimer’s
30
April 2013.
Why are women at greater risk for Alzheimer's disease?...
ApoE Does Not Bind Aβ, Competes for Clearance
29
April 2013.
Rather than sequestering Aβ to prevent its clearance from the brain, ApoE may indirectly block the peptide’s path to breakdown...
Does Progranulin Play Both Sides in AD and FTD?
26
April 2013.
Mutations that cause frontotemporal dementia may also predispose carriers to Alzheimer’s dementia...
Newborn Healers—Novel Astrocytes Repair Brain Injury
26
April 2013.
When leaky blood vessels damage the brain, the organ’s stem cell niche dispatches a specialist crew of astrocytes to stop the bleeding...
Cholinergic Neurons From Stem Cells Rescue Mouse Memories
26
April 2013.
A new recipe for cooking up cholinergic neurons from stem cells may help researchers study what goes wrong with these cells in Alzheimer’s disease...