News just reached me this morning of Anne's passing, through this forum.

I worked with Anne, and her future husband Pete, way back when we were just kids in Randy Nixon's lab. She was such a joy and so wonderful to work with. She sent a Christmas card to me every year. I had just visited McLean a few months ago, and Pete brought me to her lab during a tour of the place. I hadn't seen her in so many years, and she was just as bright and energetic and wonderful as over 20 years ago.

The world is less without her. My heart goes out to Pete.

View all comments by Tom Shea

This is a staggering loss to our AD research family. The importance of Anne's work is exceeded only by the warmth of her collegial disposition. She will be missed dearly by the research community, replete with friends and collaborators whose lives and careers Anne enriched.

View all comments by Steve Barger

I was shocked and deeply saddened to hear of Anne's death.

Anne and I were graduate students in the same laboratory at the University of Maryland School of Medicine in Baltimore during the early and mid 1980’s. Annie, as I affectionately called her, was one of the first people that I met upon entering the Department of Pathology and Laboratory Medicine and we quickly became friends. We both were students in the neuropathology lab of Richard Broadwell and worked on projects addressing the cellular biology of the blood-brain barrier. Annie was already in the lab when I first started. She quickly took me under her wing and instructed me on the different histochemical, cytochemical and ultrastructural techniques that she was performing. This is when I realized that Annie was a great teacher, having the characteristics of commitment, patience and humility.

She also was a great friend. Annie would do anything for anyone in need and she really cared about others’ feelings. Our graduate school days were filled with worries about experiments, getting posters and grants finished...  Read more

I was shocked and deeply saddened to hear of Anne's death.

Anne and I were graduate students in the same laboratory at the University of Maryland School of Medicine in Baltimore during the early and mid 1980’s. Annie, as I affectionately called her, was one of the first people that I met upon entering the Department of Pathology and Laboratory Medicine and we quickly became friends. We both were students in the neuropathology lab of Richard Broadwell and worked on projects addressing the cellular biology of the blood-brain barrier. Annie was already in the lab when I first started. She quickly took me under her wing and instructed me on the different histochemical, cytochemical and ultrastructural techniques that she was performing. This is when I realized that Annie was a great teacher, having the characteristics of commitment, patience and humility.

She also was a great friend. Annie would do anything for anyone in need and she really cared about others’ feelings. Our graduate school days were filled with worries about experiments, getting posters and grants finished on time, and about writing manuscripts that wouldn’t come back entirely in red from our advisor. Having Annie there certainly made it more fun and worthwhile. She was always the calming presence in our usual state of controlled chaos. There were times during which we would just stop and look at each other and break out laughing, she truly had the knack for keeping everything in perspective.

After graduate school, we both went on to postdoctoral fellowships that led us to Alzheimer disease research. Interestingly, the directions we took were definitely not mainstream, but rather a reflection of taking a more unorthodox approach to the problem. Annie was very creative and technically skilled even from her graduate school days, and her contemporary work on endosomal and lysosomal protein processing in AD certainly reflected that well. She and I often discussed her work at various scientific conferences as her work was a revolutionizing force in how we started thinking about the lysosomal system and autophagy in neurodegenerative disease. Annie had great scientific acumen that was readily apparent in discussions with her about her work. She was always enthusiastic and generous with her time for others.

Her legacy goes well beyond her accomplishments as she was not only a fabulous scientist, but also a wonderful colleague and friend. I feel blessed to have known Annie Cataldo, and I, like so many others, will miss her dearly.

View all comments by Brian Balin

“One of the kindest colleagues I ever had” wrote a friend of mine today upon learning of Anne’s untimely passing. If you were lucky enough to collaborate with Anne, you soon came to know that her unique kindness, humor, and dedication to the relationship always went hand in hand with her passion for moving science forward creatively. How lucky it was, then, for me to enjoy a scientific partnership with Anne that spanned 25 years and continually brought pleasant surprises about the broader significance of lysosomal system pathology in Alzheimer disease described by Anne in the early days of protease research.

Anne’s explorations of vesicular trafficking began as a graduate student in Richard Broadwell’s laboratory. There, her meticulous studies of osmotic challenge in the brain provided insights about how stressed neurons mobilize ER and lysosomal pathways, which she would later bring to bear on her AD research. Our mutual interests led Anne to come to McLean Hospital for postdoctoral training and to study why cathepsins, which are normally localized to lysosomes within...  Read more

“One of the kindest colleagues I ever had” wrote a friend of mine today upon learning of Anne’s untimely passing. If you were lucky enough to collaborate with Anne, you soon came to know that her unique kindness, humor, and dedication to the relationship always went hand in hand with her passion for moving science forward creatively. How lucky it was, then, for me to enjoy a scientific partnership with Anne that spanned 25 years and continually brought pleasant surprises about the broader significance of lysosomal system pathology in Alzheimer disease described by Anne in the early days of protease research.

Anne’s explorations of vesicular trafficking began as a graduate student in Richard Broadwell’s laboratory. There, her meticulous studies of osmotic challenge in the brain provided insights about how stressed neurons mobilize ER and lysosomal pathways, which she would later bring to bear on her AD research. Our mutual interests led Anne to come to McLean Hospital for postdoctoral training and to study why cathepsins, which are normally localized to lysosomes within cells, were so abundant extracellularly in senile plaques. Nearly 50 publications later, the picture has clarified considerably, revealing disturbances in both endocytic and autophagic pathways to the lysosome, each of which can be tied closely to the major genetic and environmental risk factors for AD.

Tracing the extracellular cathepsin in AD first to a robustly mobilized neuronal lysosome system, Anne further sleuthed upstream of this lysosomal response, revealing disease-specific abnormalities of neuronal endosomes that precede other known AD-related neuropathologies. In studies published last year, she showed that the characteristic enlargement of endosomes in Down syndrome, which begins decades before AD onset, reflects a robust rab5-mediated acceleration of endocytosis that not only mobilizes the lysosome system but contributes to its dysfunction (Cataldo, 2008). In the intervening years between these observations, Anne’s work established clear pathogenic relevance of the endocytic dysfunction by showing its dependence on the extra copy of APP in a Down syndrome animal model. Recent studies by Bill Mobley’s group further linked this APP-driven endosome dysfunction to the degeneration of forebrain cholinergic neurons through a failure of endosome-mediated neurotrophin signaling. The collaborations of Rachael Neve’s group with Anne provided additional clues about molecular components linking high APP expression and mutant APP to endosome dysfunction and to further adverse cellular consequences of deranged endosomal signaling.

Anne’s findings on endocytosis and the many emerging directions of research on autophagy in AD that have developed from her early investigations of the lysosomal system continue to gain relevance as an important path toward understanding AD pathogenesis. They increasingly inform the work of a growing number of scientists who are now investigating the consequences of disturbed endocytic and autophagic function, not only in relation to neurodegeneration in the β-amyloidoses but in other dementias and neurodegenerative disorders. Anne’s interests in recent years were beginning to turn more translational to include the use of stem cells and other cellular vehicles to deliver trophic factors and other homeostatic agents to compromised neurons in vivo. These many research avenues will continue in the labs of her collaborators and beyond.

As important and enduring as these scientific contributions are, colleagues of Anne will agree that she placed the relationships in a collaboration above the science. She regularly traded personal time, comfort, and gain to offer help and advice, not just scientific, to collaborators and staff, which was always seasoned with her signature humor and self-effacing manner. Whether she was setting out before dawn from Boston to New York to get in a full day of discussions with NKI collaborators, or delaying the long return drive so that she could spend more time trouble-shooting problems with colleagues, Anne continually redefined the extremes of commitment and dedication to friends, even as medical problems intervened that would have slowed most others. Recognizing her technical savvy, many in the worldwide AD community also became beneficiaries of her generosity in sharing skills and wisdom. Everyone who spent time with Anne thought that they had a special relationship with her.

Anne leaves us a legacy of assuredly important scientific contributions and a second legacy of a large family of scientists who have shared the gift of knowing this beautiful person and will always feel blessed.

View all comments by Ralph Nixon

Anne represented an ideal scientist and person. Scientifically, her major contribution is her imaginative work on autophagy and lysosome systems in Alzheimer disease—work that was initiated decades before these became hot topics. Anne represented an optimal balance between being an outstanding scientist and a warm and open human being. She is sorely missed.

View all comments by Paul Coleman

I am deeply saddened by the untimely passing of Anne. She was a friend and collaborator, with a calm and caring demeanor and a great sense of humor. Anne was tremendously generous with her resources, always willing to share reagents and experimental data to support ongoing studies. Most of all, Anne was tremendously generous with her time. She literally spent hours of her own valuable percentage of effort helping out her friends and colleagues, as well as helping to train and support postdoctoral fellows and graduate students. She was as adept at the microscope taking digital images of basal forebrain cholinergic neurons in mouse models of Down syndrome as she was evaluating biochemical measures of endosome enlargement in fibroblasts transfected with viral vectors.

Her tireless work ethic and contributions to the field of endosomal, autophagic, and lysosomal systems (EALS) pathology in Alzheimer disease and Down syndrome are irreplaceable. Anne also left the funniest voice messages, and I truly wish I could listen to all of them that I have received throughout the years over...  Read more

I am deeply saddened by the untimely passing of Anne. She was a friend and collaborator, with a calm and caring demeanor and a great sense of humor. Anne was tremendously generous with her resources, always willing to share reagents and experimental data to support ongoing studies. Most of all, Anne was tremendously generous with her time. She literally spent hours of her own valuable percentage of effort helping out her friends and colleagues, as well as helping to train and support postdoctoral fellows and graduate students. She was as adept at the microscope taking digital images of basal forebrain cholinergic neurons in mouse models of Down syndrome as she was evaluating biochemical measures of endosome enlargement in fibroblasts transfected with viral vectors.

Her tireless work ethic and contributions to the field of endosomal, autophagic, and lysosomal systems (EALS) pathology in Alzheimer disease and Down syndrome are irreplaceable. Anne also left the funniest voice messages, and I truly wish I could listen to all of them that I have received throughout the years over and over again. Anne will be sorely missed, but her memory lives on in the hearts and minds of her family, friends, and collaborators.

View all comments by Stephen D. Ginsberg

I feel honored to have known as fine a scientist and as fine a person as Anne Cataldo. Her work was top-rate, and she showed me, as I am sure she did all those with whom she was even closer friends, generosity and sagacity. Her magnum opus, autophagy and its relevance to Alzheimer's, will doubtless continue as an important avenue of research. We are so lucky to have had her blaze this trail for us.

View all comments by Sue Griffin

The last time I saw Anne, I stopped by unannounced in her lab at McLean. She was talking to someone from her lab, and she kindly introduced me to him, and then asked him to leave so we could talk, which we did for two hours. Seeing Anne was like coming home: that's where you wanted to be, and there was time for you.

She was so smart about her work, and unconcerned about how much recognition and credit she got. She just kept working on interesting ideas, assuming good ideas and good data were enough. And she just kept taking time for us...

View all comments by G. William Rebeck

I wish to join the chorus eulogizing Anne. Though not closely associated with her work, I am still impressed by her accomplishments and the loss suffered by the AD community. Her work on endocytic dysfunction in neurons and fibroblasts and her insights may help to clarify posthumously defective phagocytosis and clearance of amyloid-beta by macrophages of patients with AD.

View all comments by Milan Fiala

It is with great sadness that I learned of Anne's passing. We were colleagues at the NKI. She always had a smile and a positive attitude. She was one of those people you would always like to have around. She was a great scientist and contributed to the advancement of knowledge throughout her life. Her work on autophagy and the lysosome system in Alzheimer disease was seminal, building a base of data for this very worthwhile research. More recently, she performed pioneering research on stem cells and Alzheimer disease, which I liked very much.

She will be greatly missed, both as a colleague and a friend. She was happy doing her work, which is very important in life, and she was able to contribute to the improvement of humankind as a researcher. Therefore, her life energy remains with us and her contributions will be combined with the work of others to contribute now and to lives further into the future.

View all comments by Ottavio Arancio

Anne was a very kind woman and a brave and creative scientist. She was a pioneer in the cell biology of Alzheimer's and neurodegenerative disease, and her work will provide a long legacy for people trying to understand the causes and pathogenesis of these diseases. I'm so sorry to read that she passed away, and hope that her friends and family will realize from our letters what an important contribution she was making to create therapies to alleviate suffering and help provide better lives for people in the future.

View all comments by David Sulzer

It is heartwarming and gratifying to see how many friends and collaborators she helped and influenced over the years. My own personal loss is particularly deep, but I realize others are grieving, too. I'm sure her work will be carried on by others, for the greater good of all.

View all comments by Peter Paskevich

It is impossible to give words to feelings under these conditions. Although my personal interactions with Ann were brief and periodic, they were extraordinarily memorable. She was kind, open and great for discussion. She will certainly be missed.

Peter, I am sending you my most heartfelt condolences for your great loss. Although we can all grieve her loss as a brilliant and generous colleague, I know and feel with you the irreplaceable emptiness of someone so near and dear and can only imagine the effects on you.

View all comments by Kumar Sambamurti