22 December 2005. Today, a study summarized in our SfN Conference News appeared in Neuron. First author John Cirrito, working with Dave Holtzman, Steven Paul, and colleagues at Washington University in St. Louis, Missouri, and Lilly Research Laboratories in Indianapolis, used an in-vivo microdialysis system to discover that increasing synaptic activity drives up levels of Aβ in the interstitial fluid within minutes. The mechanism is unclear but possibly tied to presynaptic vesicle exocytosis, the authors suggest. Read the ARF conference story for a broader description of how the focus of Aβ research is shifting toward synaptic biology, and ponder the questions such studies raise about mental activity and neurodegeneration.—Gabrielle Strobel.
Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM. Synaptic Activity Regulates Interstitial Fluid Amyloid-beta Levels In Vivo. Neuron. 2005 Dec 22;48(6):913-92. Abstract