Antibody

acetylated Tau /ac-tau

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Clonality: polyclonal
Host: Rabbit
Source: 9AB
Li Gan, Gladstone Institute of Neurological Disease Assistant Professor of Neurology University of California, San Francisco
Reference:
Min SW, 2010
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = the microtubule-binding region aa 264–287 (ENLKHQPGGG VQIINKLDLSNV), which is 100% conserved between mouse and human

Specificity

9AB recognizes recombinant tau acetylated by GST-p300, but not tau incubated with GST alone, suggesting that 9AB does not cross-react with non-ac-tau. 9AB also preferentially recognizes p300-induced ac-tau in cultured cells. In mouse brains, 9AB detected low levels of ac-tau. Does not recognize nonacetylated recombinant tau

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References

Paper Citations

  1. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23;67(6):953-66. PubMed.

External Citations

  1. Li Gan

Further Reading

No Available Further Reading