Just Like Viruses, Tau Can Unleash Interferons
By triggering release of mitochondrial DNA, tau fibrils may set off a cytosolic sensor that activates the interferon response. Blocking this sensor spared neurons and memory in mice.
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Scientists Re-Analyze Aduhelm Data, Try to Parse Who Benefits
At AD/PD, some speakers sought to bolster the argument that amyloid removal slows cognitive decline, while others identified what type of patient is most likely to benefit.
Using Lecanemab Trial Data to Determine Maintenance Dose
At AD/PD, researchers presented pharmacologic analyses that could help predict antibody effects and select the right dosage to keep plaques at bay.
In First for the Field, α-Synuclein PET. Only for Multiple System Atrophy
A new tracer detects α-synuclein aggregates in people with multiple system atrophy. Binding is weak, and undetectable in people with other synucleinopathies.
TAPAS Anyone? PyroGlu-Aβ Vaccine Shrinks Plaques in Mice
The new vaccine stalled neurodegeneration and improved learning. An antibody that binds the same epitope had similar effects, and only binds soluble oligomers.
AD/PD 2022: Advances in Science and Therapy (Hybrid Virtual and In-Person)
Gantenerumab Prevention Trial in Sporadic Alzheimer's Begins In First for the Field, α-Synuclein PET. Only for Multiple System Atrophy Using Lecanemab Trial Data to Determine Maintenance Dose Scientists Re-Analyze Aduhelm Data, Try to Parse Who Benef
Gantenerumab Prevention Trial in Sporadic Alzheimer's Begins
Taking a stab at secondary prevention, the four-year Phase 3 trial will assess the antibody’s ability to slow slippage in 1,200 cognitively healthy, amyloid-positive people.
Like GWAS, BWAS Need Thousands of Participants
To find true brain-behavior correlations, a brain-wide association study needs orders of magnitude more people than the dozens typically used in neuroimaging research.
Field Loses GSM Developer Steven Wagner, 64
Wagner pioneered γ-secretase modulators to treat Alzheimer’s disease, with a candidate slated to enter Phase 1 trials later this year.
Robust TREM2 Expression May Delay Alzheimer’s Disease
In familial AD, the faster sTREM2 rises in a person's cerebrospinal fluid, the slower his or her amyloid grows, cortex thins, and cognition fades.
Can Preserving Vision and Hearing Prevent Dementia?
Removing cataracts cuts a person's risk of dementia. Cochlear implants stall mild cognitive impairment. Could treating sensory losses hold some dementia cases at bay?
Mild COVID Infection Can Shrink Brain, Speed Cognitive Decline
In some people who had weathered COVID at home, olfactory regions in the brain shrank and executive function slowed. Will these changes resolve or persist?
Tau Haplotypes Hint at Transcriptional Changes, Ferroptosis
In iPSC-derived cells, H1 risk haplotype is linked to noncoding, antisense variants and to a master regulator of oxidative stress
Tau Triggers Neuroinflammation, But Mechanisms Vary by Disease
In two primary tauopathies, natural killer cells invade the brain. In Alzheimer’s, a microglial antiviral response dominates, and hyperexcitability may play a role.
Tau2022 Global Conference (Virtual Meeting)
P-Tau217 Clock Predicts Alzheimer’s Progression Over 30 Years At Tau2022: Unknown Functions Emerge for Tau, LRRK2 Tau Triggers Neuroinflammation, But Mechanisms Vary by Disease Tau Haplotypes Hint at Transcriptional Changes, Ferroptosis Since Tau2020 was
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