New Partnership Forms to Harness AI for Alzheimer’s Research
Drawing in researchers in academia, pharma, and AI companies, a nascent consortium aims to speed up discoveries in complex diseases. Smaller AI projects report data at AD/PD.
NEWS
Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s
Several tracers detect the low level of α-synuclein aggregates present in sporadic disease. None are ready for clinical use.
Zapping the Zoster Virus, Dodging Dementia
Among people vaccinated against shingles in Wales, there were 20 percent fewer dementia diagnoses over the next seven years.
Tau-PET and P-tau217—Equally Predictive, Yet Complementary
In a head-to-head comparison, the two markers similarly predicted cognitive decline in healthy people. Still, using them sequentially might best identify who will benefit from therapy.
Do Synaptic Markers Foreshadow Cognitive Decline?
Ratio of two peptides in cerebrospinal fluid increases with age, a change accelerated by Alzheimer’s disease.
Donanemab Clinical Use Growing in U.S., Rejected in Europe
Donanemab prescriptions have been slow to ramp up, but demand is growing due to an easier dosing schedule than for lecanemab.
Plaque Removal Delays Onset of Familial Alzheimer’s Disease
Healthy people who carry an autosomal-dominant AD mutation halved their odds of developing symptoms when they took gantenerumab for eight years.
Filling in the Family Tree: AD, CTE Folds Spotted in Other Tauopathies
Core structures of protofilaments from more diseases prompt an update to the family tree of tau filaments.
SPOTLIGHT
Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s
Scientists can now peek at pathology in people living with sporadic Parkinson’s disease. In pilot studies, several tracers light up the sparse aggregates in the substantia nigra of these patients. All the candidates still need tweaking, but the rapid progress suggests a reliable a-synuclein tracer is not far off.
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