Tau PET as Progression Marker: It’s the Spread, Not the Brightness
The spatial extent of tau pathology better correlates with disease severity, and stages disease more accurately, than does tangle load. Trials are starting to use this measure.
NEWS
Commander Complexes in Lysosomes Stave Off Parkinson’s Risk
Decreased lysosomal efficiency could result from shifts in endosomal recycling.
Trial-Eligible Genetic Variants Now Marked in Alzforum Mutations Database
DIAN-TU explains how it selects APP, PSEN1, and PSEN2 genetic variants for clinical trial inclusion; unveils a list.
Trialists Grapple with How to Outsmart TREM2, the Trickster
After one TREM2 agonist antibody nose-planted, a new batch of therapies appear safe so far in first-in-human data. The drugs exert different effects on the receptor and soluble TREM2.
TREM2: A Chill Pill for Neurons?
In mouse models, the microglial receptor counteracts their hyperexcitability. Both transmembrane and soluble TREM2 appear to help with this.
Moving Target: New Biology Casts TREM2 as a Shifty Mark
At AD/PD, scientists reported that TREM2 expressed on plaque-associated microglia becomes desensitized to agonist antibodies. They also suspect the receptor calms hyperactive neurons.
New Partnership Forms to Harness AI for Alzheimer’s Research
Drawing in researchers in academia, pharma, and AI companies, a nascent consortium aims to speed up discoveries in complex diseases. Smaller AI projects report data at AD/PD.
Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s
Several tracers detect the low level of α-synuclein aggregates present in sporadic disease. None are ready for clinical use.
SPOTLIGHT
Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s
Scientists can now peek at pathology in people living with sporadic Parkinson’s disease. In pilot studies, several tracers light up the sparse aggregates in the substantia nigra of these patients. All the candidates still need tweaking, but the rapid progress suggests a reliable a-synuclein tracer is not far off.
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