Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?

• 23 Comments

25 Mar 2006

Leuven, Belgium. The goal of this discussion is to explore the implications of two recent papers, which

Presenilin Loss of Function—Plan B for AD?

• 21 Comments

09 Mar 2007

a lively Alzforum discussion when Peter Davies initiated a conversation about a paper from Bart de

Messing with the Membrane—An Alternative Interpretation of the Amyloid-β Hypothesis

• 20 Comments

01 Nov 2006

We invite you to participate in this "offline" Forum discussion led by Vincent Marchesi of Yale University. Coming from a different research field, Marchesi has in recent years followed the AD literature as closely as have few other outside obse

Herpes Simplex and Alzheimer’s—Time to Think Again?

• 14 Comments

15 Apr 2011

On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared som

Cell Death: Time to Push It Out of the Doldrums

• 10 Comments

10 Sep 2004

We invite you to participate in this Forum Discussion with Yong Shen (Sun Health Research Institute). This discussion will not be hosted via our live discussion software. Instead, we will develop written exchanges between our participants and Yong Shen. T

Reimagining Alzheimer's Disease—Time for Bright New Ideas?

• 9 Comments

03 May 2011

Alois Alzheimer made a major breakthrough when he discovered senile plaques in the brains of dementia patients, and his work ultimately led to the discovery of amyloid-β and to the amyloid cascade hypothesis. But that cascade is only part of a much bigger

Calcium Signaling Deficit in the Origin of Alzheimer's Disease

• 8 Comments

07 Sep 2001

Live discussion and panel of participants scheduled for 7 September 2001.     Summary: "Ca2+ deficit" hypothesis Summary: "Natural origin" hypothesis for plaques and tangles The live chat and panel of participants scheduled for 7 Septe

Seeded Aggregation and Transmissible Proteopathy—Creepy Stuff Not Just for Prions Anymore?

• 7 Comments

30 Sep 2009

proteopathies. Trends Neurosci. 2006 Aug;29(8):438-43. Abstract Selected Primary Papers on Seeding: Bolmont T,

β Amyloid Degradation: The Forgotten Half of Alzheimer's Disease

• 7 Comments

12 Sep 2002

thanks.. I was just looking at an older Selkoe paper concluding IDE mostly works extracellularly. Gabrielle

The Cell Cycle and Alzheimer’s Disease—Let's Unite for Division!

• 6 Comments

07 Aug 2002

die but without forming NFT. (paper under review). Craig Atwood: Inez, for amyloid in Niemann-Pick

The AD8—Dementia Screen Ready for Prime Time?

• 6 Comments

02 Dec 2010

Have you been waiting for a quick yet reliable test for early dementia? The AD8 might be your answer. The interview-based screening tool detects early cognitive impairment, has been validated against the clinical dementia rating scale and against neuropsy

Calcium in AD Pathogenesis

• 5 Comments

09 Dec 2008

yes, Cell Calcium paper from De Smedt's group (see Kasri et al., 2006). Please see detailed

In Search of γ-Secretase

• 5 Comments

05 May 1999

panelists with a remark? Otherwise, we'll go on.... Hardy: COMMENT The Nature paper reported

Nomenclature Discussion

• 5 Comments

15 Aug 2001

pre-medline is out! June: I can live with that. Colin Masters: Just review the last hundred papers. Msmith:

Gonadal Hormone Withdrawal, Apoptosis, and Generation of Beta Amyloid Peptide: A Vicious Cycle of Amyloidogenesis and Neurotoxicity in Alzheimer's Disease

• 5 Comments

05 Dec 2001

gonadotrophin levels under any circumstances. A paper on ovariectomy effects on Ab load in transgenic mice is in