Weeding Mendel’s Garden: Can We Hoe Dubious Genetic Associations?
original papers and understand enough to know whether you can trust it. Marc Cruts: I believe that it is
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original papers and understand enough to know whether you can trust it. Marc Cruts: I believe that it is
the papers and an accompanying editorial freely available for download to Alzforum readers until 15
all papers reporting the effects of aggregated proteins clearly state the exact source of the protein,
in the Phase 3 trial. However, I also refer to our Nature Reviews Drug Development paper, where I lay
generously granted free access to Castellano et al. for Alzforum readers. For a brief summary of the paper
its role in AD pathogenesis. The Guest Moderator was David Holtzman. Paper Under Discussion.
2011). The papers followed a previous release of draft guidelines at the July 2010 ICAD conference in
When two biological networks as complex as the nervous and immune systems cross paths, you know the interaction is not going to be simple. Add in neurodegeneration—such as amyotrophic lateral sclerosis—and it creates a web that will take many scientists t
Alois Alzheimer made a major breakthrough when he discovered senile plaques in the brains of dementia patients, and his work ultimately led to the discovery of amyloid-β and to the amyloid cascade hypothesis. But that cascade is only part of a much bigger
On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared som
Have you been waiting for a quick yet reliable test for early dementia? The AD8 might be your answer. The interview-based screening tool detects early cognitive impairment, has been validated against the clinical dementia rating scale and against neuropsy
LP, etc.)? A: This is published in the Nature Rev Neurol paper (see Blennow et al., 2010). Q: We are
As Tolstoy wrote in Anna Karenina, “Happy families are all alike; every unhappy family is unhappy in its own way.” The same might be said of the brain. Normal brains look and behave similarly, but those affected by different neurodegenerative diseases are
measure as a primary outcome in this population. Notably, a recent paper demonstrates the utility of
One hundred years ago, in January of 1907, Alois Alzheimer published his landmark paper about
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