The Role of ApoE in Alzheimer's Disease: An Alternative View

11 Dec 2001

Alzheimer's neuropathology and is not simply a supporting actor. If this were true, one would expect that

Gonadal Hormone Withdrawal, Apoptosis, and Generation of Beta Amyloid Peptide: A Vicious Cycle of Amyloidogenesis and Neurotoxicity in Alzheimer's Disease

• 5 Comments

05 Dec 2001

Alzheimer's incidence in normal humans, and I'd be skeptical about claims to that effect in Down's.

Calcium Signaling Deficit in the Origin of Alzheimer's Disease

• 8 Comments

07 Sep 2001

when Ca2+ signal is reduced, tau will accumulate and at the same time become hyperphosphorylated. 6.

Nomenclature Discussion

• 5 Comments

15 Aug 2001

a good idea. Pick certain journals and for a specified time period see what is the most common usage in

New Theories of Presenilin Function

12 Dec 2000

a chance to address. Imaizumi: I think [they are] differences of treatment of stressors, dose and time

Generation of an Apoptotic Intracellular Peptide by γ-secretase Cleavage of Alzheimer's β-amyloid Precursor Protein

20 Sep 2000

huntingtin is turned off and the inclusions go away. Soshi: World Alzheimer Congress meeting data suggest

Intracellular Aβ in Alzheimer's Disease

• 3 Comments

16 May 2000

has been edited for clarity and accuracy. Charles Glabe: Hi! Hey Austin! Austin: Hi boss. Charles

Protofibrillar Aβ in Alzheimer's Disease

17 Feb 2000

Dennis Selkoe, Dean Hartley, and William Klein led this live discussion on 17 February 2000.

Beta-Catenin and PS1

13 Aug 1999

inducible system, the length of time of induction and level of induction also provides varying results. Our

Pin1, Tau and the Cell Cycle in Alzheimer Disease

03 Aug 1999

proteins, in normal and Alzheimer states; and Pin1 and the paradigm of phosphorylation-dependent prolyl

In Search of γ-Secretase

• 5 Comments

05 May 1999

some responses on other topics? Perhaps a role for ApoE? The connection of Alzheimer's disease and

Apoptosis in Alzheimer Disease

24 Mar 1999

so. The neurons are alive! Carl Cotman: Perhaps a very long time. This is the point: There are DNA and

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down's Syndrome Patients

28 May 1998

protein and ubiquitin-B in Alzheimer's and Down's syndrome patients. Science 1998 Jan 9;279

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

20 Mar 1998

Ma J. and Potter H. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and

Isolation of Single Immunohistochemically Identified Whole Neuronal Cell Bodies from Post-Mortem Human Brain for Simultaneous Anlaysis of Multiple Gene Expression

27 Feb 1998

and I saw some time ago was that ACT antibodies sometimes stained neuronal cell bodies. Nienwen