Therapeutics
Search By Attributes
Search Results
| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| ABT-089 | Alzheimer's Disease (Discontinued) | Abbott Laboratories | Cholinergic System | Small Molecule | ||
| ABT-288 | Alzheimer's Disease (Discontinued) | AbbVie | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| ABT-384 | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | ||
| ABT-957 | Alicapistat | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | |
| ABT 418 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
| AF 102B | cevimeline HCL, Evoxac™ |
Alzheimer's Disease (Discontinued) | SnowBrand Pharmaceuticals, Inc. | Cholinergic System | Small Molecule | Treatment of dry mouth in Sjogren's syndrome. |
| Atabecestat | JNJ-54861911 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Janssen, Shionogi Pharma | Amyloid-Related | Small Molecule | |
| Atuzaginstat | COR388 | Alzheimer's Disease (Discontinued) | Cortexyme, Inc., Quince Therapeutics | Other | Small Molecule | |
| Avagacestat | BMS-708163 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Amyloid-Related | Small Molecule | |
| AVP-786 | Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) | Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Combination, Small Molecule | ||
| AZD1446 | TC-6683 | Alzheimer's Disease (Discontinued) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | None |
| Azeliragon | PF-04494700, TTP488 |
Alzheimer's Disease (Discontinued) | Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC | Amyloid-Related, Inflammation | Small Molecule | |
| Besipirdine HCl | HP 749 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
| BI 409306 | SUB 166499 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters, Other | Small Molecule | |
| BI 1181181 | VTP 37948, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Boehringer Ingelheim, Vitae Pharmaceuticals | Amyloid-Related | Small Molecule | |
| Celecoxib | Celebrex | Alzheimer's Disease (Discontinued) | Pfizer | Inflammation | Small Molecule | Pain, Arthritis |
| Clioquinol | iodochlorhydroxyquin, PBT-1 |
Alzheimer's Disease (Discontinued) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| CX516 | Ampalex | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | None |
| Dimebon | Dimebolin, Latrepirdine, Pf-01913539 |
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) | Medivation, Inc. | Other Neurotransmitters, Unknown | Small Molecule | Anti-histamine use in Russia |
| Edonerpic | T-817 MA, T 817 | Alzheimer's Disease (Discontinued) | Toyama Chemical Co., Ltd. | Other, Unknown | Small Molecule | |
| Elenbecestat | E2609, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Biogen, Eisai Co., Ltd. | Amyloid-Related | Small Molecule | |
| Encenicline | EVP-6124 , MT-4666, α7-nAChR agonist |
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) | FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma | Cholinergic System | Small Molecule | None |
| Epothilone D | BMS-241027 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Tau | Small Molecule | |
| Eptastigmine | MF 201 | Alzheimer's Disease (Discontinued) | Mediolanum | Cholinergic System | Small Molecule | None |
| EVP-0962 | EVP 0015962 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | FORUM Pharmaceuticals Inc. | Amyloid-Related | Small Molecule | |
| Flurizan™ | tarenflurbil , r-flurbiprofen, MPC-7869 |
Alzheimer's Disease (Discontinued) | Myriad Genetics & Laboratories | Amyloid-Related | Small Molecule | None |
| Fosgonimeton | ATH-1017, NDX-1017 |
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued), Parkinson's Disease Dementia (Discontinued) | Athira Pharma | Other | Small Molecule | |
| GSK239512 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| HF0220 | Alzheimer's Disease (Discontinued) | Newron | Inflammation | Small Molecule | ||
| Ibuprofen | Advil™, Nuprin™ , Motrin™ |
Alzheimer's Disease (Discontinued) | Amyloid-Related, Inflammation | Small Molecule | Pain and Fever | |
| Iclepertin | BI 425809 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 3) | Boehringer Ingelheim | Other Neurotransmitters | Small Molecule | |
| Idalopirdine | Lu AE58054, SGS 518 |
Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | |
| Idebenone | Catena, Sovrima |
Alzheimer's Disease (Discontinued) | Takeda Pharmaceutical Company | Other | Small Molecule | None |
| Intepirdine | RVT-101, SB 742457 , GSK 742457 |
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued) | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | |
| Inzomelid | Emlenoflast, IZD174, MCC-7840 |
Alzheimer's Disease (Discontinued), Parkinson's Disease (Discontinued) | Hoffmann-La Roche, Inflazome Ltd. | Inflammation | Small Molecule | |
| Ladostigil | Ladostigil hemitartrate, TV3326 |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) | Avraham Pharmaceuticals Ltd | Cholinergic System | Small Molecule | |
| Lanabecestat | AZD3293 , LY3314814, BACE inhibitor |
Alzheimer's Disease (Discontinued) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| Linopirdine | DuP996 | Alzheimer's Disease (Discontinued) | Other | Small Molecule | None | |
| Lornoxicam | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | JSW Lifesciences | Inflammation | Small Molecule | Pain in US | |
| LU25-109 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
| Lu AF88434 | Mild Cognitive Impairment (Discontinued) | Lundbeck | Other | Small Molecule | ||
| LY2886721 | BACE inhibitor | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| LY3202626 | BACE Inhibitor | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| MEM 1003 | BAY Z 4406 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) | Memory Pharmaceuticals Corporation | Other | Small Molecule | None |
| Metrifonate | trichlorfon | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | |
| Milameline | CI 979 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Cholinergic System | Small Molecule | None |
| Minocycline | Solodyn, Arestin, Minocin, Dynacin |
Alzheimer's Disease (Discontinued) | Other | Small Molecule | ||
| MK-1942 | Alzheimer's Disease (Discontinued) | Merck | Unknown | Small Molecule | ||
| MK-7622 | Alzheimer's Disease (Discontinued) | Merck | Unknown | Small Molecule | ||
| Naproxen | Aleve™, Anaprox™, Naprosyn™ |
Alzheimer's Disease (Discontinued) | Procter & Gamble | Inflammation | Small Molecule | Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness. |
| Nefiracetam | Alzheimer's Disease (Discontinued) | Daiichi Sankyo Pharmaceuticals | Cholinergic System | Small Molecule | None | |
| Nelonicline | ABT-126 | Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | AbbVie | Cholinergic System | Small Molecule | |
| NeoTrofin | AIT-082, leteprinim |
Alzheimer's Disease (Discontinued) | NeoTherapeutics, Inc. | Unknown | Small Molecule | None |
| Neramexane | MRZ 2/579 | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc., Merck | Other Neurotransmitters | Small Molecule | None |
| NS2330 | Tesofensine | Alzheimer's Disease (Discontinued) | NeuroSearch A/S | Other Neurotransmitters | Small Molecule | |
| PF-05212377 | PF-5212377, WYE-103760, SAM-760 |
Alzheimer's Disease (Discontinued) | Pfizer | Other Neurotransmitters | Small Molecule | |
| PF-06648671 | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | ||
| PF-06751979 | BACE inhibitor | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | |
| PF-06852231 | Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | ||
| Physostigmine Salicylate | Synapton | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc. | Cholinergic System | Small Molecule | |
| Prednisone | Alzheimer's Disease (Discontinued) | Inflammation | Small Molecule | |||
| Propentofylline | HWA 285, PPF |
Alzheimer's Disease (Discontinued) | Unknown | Small Molecule | ||
| PXT864 | PXT00864 | Alzheimer's Disease (Discontinued) | Pharnext | Other Neurotransmitters | Combination, Small Molecule | |
| Rember TM | Methylene Blue , methylthioninium (MT), TRx-0014, Tau aggregation inhibitor (TAI) |
Alzheimer's Disease (Discontinued) | TauRx Therapeutics Ltd | Tau | Small Molecule | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
| RG7129 | RO5508887, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Roche | Amyloid-Related | Small Molecule | |
| Rilapladib | SB-659032 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| Rofecoxib | Vioxx™ | Alzheimer's Disease (Discontinued) | Merck | Inflammation | Small Molecule | Withdrawn from market |
| Rosiglitazone | Rosiglitazone maleate, Avandia |
Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| S 38093 | Alzheimer's Disease (Discontinued) | Servier | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| S47445 | CX1632 | Alzheimer's Disease (Discontinued) | Cortex Pharmaceuticals, Inc., Servier | Other Neurotransmitters | Small Molecule | |
| Saracatinib | AZD0530 | Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) | AstraZeneca | Other | Small Molecule | |
| SB 202026 | Memric | Alzheimer's Disease (Discontinued) | Other Neurotransmitters | Small Molecule | ||
| Seltorexant | JNJ-42847922, MIN-202 |
Alzheimer's Disease (Discontinued) | Janssen | Other | Small Molecule | |
| Semagacestat | LY450139 Dihydrate , hydroxylvaleryl monobenzocaprolactam |
Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | None |
| Sembragiline | RO4602522, RG1577 |
Alzheimer's Disease (Discontinued) | Evotech AG | Other Neurotransmitters, Other | Small Molecule | |
| SGS-742 | CGP-36742, DVD-742 |
Alzheimer's Disease (Discontinued) | Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. | Other Neurotransmitters | Small Molecule | |
| Simufilam | PTI-125, sumifilam |
Alzheimer's Disease (Discontinued) | Cassava Sciences | Amyloid-Related | Small Molecule | |
| Suritozole | MD 26479 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Other Neurotransmitters | Small Molecule | |
| Thalidomide | Thalomid® | Alzheimer's Disease (Discontinued) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | |
| Tideglusib | NP031112, Nypta® , Zentylor™ , Glycogen synthase kinase 3 inhibitor, NP12 |
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) | Zeltia Group | Tau | Small Molecule | |
| Umibecestat | CNP520, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Amgen, Inc., Novartis Pharmaceuticals Corporation | Amyloid-Related | Small Molecule | |
| Varenicline | Champix™, Chantix™, Varenicline tartrate, CP-526,555, Alpha4 beta2 nicotinic receptor agonist |
Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | Smoking cessation |
| Varoglutamstat | PQ912 | Alzheimer's Disease (Discontinued) | Probiodrug AG, Vivoryon Therapeutics N.V. | Amyloid-Related, Inflammation | Small Molecule | |
| Verubecestat | MK-8931, MK-8931-009 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Merck | Amyloid-Related | Small Molecule | |
| Xaliproden | SR 57746A | Alzheimer's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule |