Therapeutics

Linopirdine

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Overview

Name: Linopirdine
Synonyms: DuP996
Chemical Name: 1-phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one
Therapy Type: Small Molecule (timeline)
Target Type: Other (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Approved for: None

Background

Findings

Linopirdine increases acetylcholine release in rat brain (Schnee & Brown, 1998). The mechanism is thought to involve linopirdine's inhibition of voltage-gated, calcium-activated, and leak K-positive currents, especially the M-type K-oositive current (IM)  (Schnee & Brown, 1998). 

Last Updated: 12 Dec 2013

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References

Paper Citations

  1. Schnee ME, Brown BS. Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. PubMed.

Further Reading

No Available Further Reading