345938 RESULTS
COMMENT Response from Rudy Tanzi In Peter Hyslop's reply to the Alzheimer Forum News article on "A2M Revisited," he states: "The Rogaeva et al paper used the SAME family based association statistical methods as Blacker et al (ie the SDT and s-
COMMENT Thanks for summarizing the three new A2M genetics papers and our reply in Nature Genetics (May 1999) in your "News" section this month. I wanted to share my thoughts on the controversy regarding the candidacy of A2M as a genetic risk factor for
COMMENT Response from Allen Roses et al. to Tanzi Comment Below please find a short, absolute rebuttal to the comments made by Rudy Tanzi. It is followed by a fairly detailed commentary on each point, including copies of relevant dated correspondence that clarify
RESEARCH NEWS 1999-05-06 Research News Last year Deborah Blacker, Rudolph Tanzi and their colleagues reported finding a strong association between a deletion of exon 18 in the gene for α2 macroglobulin (A2M) and Alzheimer's disease. The odds ratio was 3.56, comparable to the
WEBINAR 1999-05-05 Peter Nelson, with Dennis Selkoe, John Hardy, and Alain Israel, led this live discussion on 5 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion with Dennis Selkoe,
RESEARCH NEWS 1999-05-03 Research News Evidence from several sources suggests that the dorsal hippocampus is critical for the formation and storage of spatial information. In the long term, such information is believed to be transferred to the neocortex for storage. While it is a
RESEARCH NEWS 1999-04-30 Research News The armadillo gene-so named because its mutated form in fruit flies produces a phenotype with short spiky hairs, reminiscent of those on the armadillo-codes for a protein that is a homologue of the human β-catenin. These proteins and other,
COMMENT Inflammation, free radicals, and cytokines are involved in a vascular cascade producing the transformation of macrophages into foam cells between the endothelial cell layer and the basement membrane of a blood vessel leading to formation of an atheroscler
RESEARCH NEWS 1999-04-28 Research News Atherosclerotic processes are drawing the attention of some Alzheimer's researchers who point to a number of links between atherosclerotic disease and Alzheimer's disease. It is only natural then, that vitamin E, a hot topic in the
COMMENT Reply by Steven Barger Regardless of whether presenilins really are γ-secretases (for which the data seem to tipping the scales), the data seem quite clear that they are somehow involved in proteolytic processing of both APP and Notch. To me, one of the m
COMMENT Reply by E. Preddie and J. Bergmann 1. Considering what was known before, the nature of the experiments done by Wolfe and colleagues and the results obtained, it appears that the conclusion expressed by 'Ye' et al from their results is equally v
COMMENT Reply to Ratan Bhat by Rudy Tanzi: The main problem with this hypothesis is that since the time of publication of the commentary by Tuck Finch and I in Science, we now know that PS2 does not bind β- or delta-catenin (Tesco et al., J. Biol Chem., 1998). Ye
COMMENT Question from Ratan Bhat There have been suggestions that an increase in beta-catenin could mask some the mutation sites within PS1 (Tanzi and Finch in their Science comment), thereby stabilizing PS1, decreasing γ-secretase activity and subsequently β amy
RESEARCH NEWS 1999-04-23 Research News At the American Academy of Neurology meeting in Toronto, Scott Small and colleagues presented data suggesting that fMRI can distinguish early AD-related memory decline from other sources of memory decline. Citing evidence that entorhinal cor
RESEARCH NEWS 1999-04-15 Research News In the search for the elusive γ-secretase that cleaves β-amyloid precursor protein (APP), much attention has been paid to the protein Notch, which is critical in developmental pathways and has recently been found to be important in immune fu
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