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Possible New Succeptability Genes for Alzheimer's Disease

RESEARCH NEWS 1997-04-29 Research News Put these two facts together: brain energy metabolism is abnormally low in Alzheimer's patients, and if your mother had Alzheimer's you are more likely to develop it than if your father had Alzheimer's. You might then logicall

Vitamin E, Antioxidants and Alzheimer's Disease

RESEARCH NEWS 1997-04-24 Research News Results released today of a study published in the New England Journal of Medicine indicated that large doses of vitamin E may delay the time at which late-stage Alzheimer's patients must be institutionalized because of the loss of &quo

Clues from the Colombian Countryside

RESEARCH NEWS 1997-03-12 Research News An enormous extended family living in a rural community in Colombia could provide new insights into environmental and genetic factors contributing to Alzheimer’s disease. All family members who were diagnosed with the disease carried an iden

Ibuprofen Linked to Reduced Alzheimer's Risk

RESEARCH NEWS 1997-03-10 Research News Ibuprofen and related drugs may reduce a person’s risk of getting Alzheimer’s disease by 30 to 60 percent, according to a new study by researchers at Johns Hopkins University and the National Institute on Aging. But the authors strongly caut

New Guidelines Proposed for Alzheimer's Disease Postmortem Diagnosis

COMMUNITY NEWS 1997-02-21 Community News An international group of researchers* have agreed upon recommendations to revise the criteria for postmortem diagnosis of Alzheimer’s disease (AD). The meeting, convened in November 13-14, 1996, at the National Institutes of Health in Beth

ApoE4 Gene May Be Risk Factor in Only a Subset of Cases

RESEARCH NEWS 1997-02-21 Research News A new study reports that the ApoE4 gene, previously reported to be over-represented among patients with late onset Alzheimer's disease, appears to be a risk factor only among patients who developed the disease before age 70. The study e

PSEN1 A434C

MUTATIONS PSEN1 73219185_73219186 GRCh38/hg38 GC TG 73685893_73685894 GRCh37/hg19 GC TG Exon 12 Point, Double Coding Increased Aβ42 and decreased Aβ40 production in vitro, resulting in an increased Aβ42/Aβ40 ratio. Numerous diffuse plaques and neuritic plaques with

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