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PAPER Alhadidy MM, Stemmer PM, Kanaan NM
O-GlcNAc modification differentially regulates microtubule binding and pathological conformations of tau isoforms in vitro.
J Biol Chem. 2025 Feb 3;:108263. Epub 2025 Feb 3 PubMed.Yongchang Qiu
Lysoway Therapeutics, Inc.United States
David Holtzman on From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
COMMENT The meninges, especially the dura, contain a full repertoire of immune cells. However, there has been little work on the characterization and potential role of the T regulatory cell (Treg) compartment. In other organs, Tregs can restrain immune responses.
From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
RESEARCH NEWS 2025-02-05 Research News Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls to a sparse population of regulatory T cel
Marco Colonna, Patrick Rodrigues on From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
COMMENT This highly novel study provides fascinating insights into the role of regulatory T cells in maintaining brain homeostasis. The identification of a distinct meningeal Treg compartment that regulates interferon-gamma (IFN-γ) responses is particularly inter
PAPER Shibata K, Chen C, Tai XY, Manohar SG, Husain M
Impact of APOE, Klotho, and sex on cognitive decline with aging.
Proc Natl Acad Sci U S A. 2025 Feb 11;122(6):e2416042122. Epub 2025 Feb 4 PubMed.Jonathan Kipnis on From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
COMMENT This very interesting work identifies meningeal Tregs as a unique population. It is exciting that meningeal immunity is garnering so much attention from leading immunology labs such as this one. We have recently shown that some of the presented peptides i
PAPER Marin-Rodero M, Cintado E, Walker AJ, Jayewickreme T, Pinho-Ribeiro FA, Richardson Q, Jackson R, Chiu IM, Benoist C, Stevens B, Trejo JL, Mathis D
The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis.
Sci Immunol. 2025 Jan 28;:eadu2910. Epub 2025 Jan 28 PubMed.Narjes Ta
, United States
Candace Tkachuck
, United States
PAPER Rath S, Holla VV, Phulpagar P, Kamath SD, Kamble N, Muthusamy B, Yadav R, Pal PK
Clinico-genetic analysis of patients with LRRK2-related Parkinson's disease from a referral centre in India.
Parkinsonism Relat Disord. 2025 Jan 27;132:107299. Epub 2025 Jan 27 PubMed.PAPER Pillai KS, Rajeswari P, Kamble RB, Gopalan Nair Santhamma S, Chacko M, Jayakrishnan V, Ramachandran R, Avarachan A, Kishore A
Multimodality Brain Imaging Markers in Progressive Supranuclear Palsy Subtypes and Parkinson's Disease.
Mov Disord Clin Pract. 2025 Feb 4; Epub 2025 Feb 4 PubMed.PAPER Akçimen F, Paquette K, Crea PW, Saffie-Awad P, Achoru C, Taiwo F, Ozomma S, Onwuegbuzie G, Khani M, Grant S, Owolabi L, Okereke C, Oshinaike O, Iwuozo E, Lee PS, Oyakhire S, Osemwegie N, Daida K, Abubakar S, Olusanya A, Isayan M, Traurig R, Ogunmodede A, Samuel S, Makarious MB, Sa'ad F, Olanigan R, Levine K, Ogbimi EM, Vitale D, Odiase F, Koretsky MJ, Ojini F, Odeniyi O, Fang ZH, Obianozie N, Hall DA, Nwazor E, Xie T, Nwaokorie F, Padmanaban M, Nwani P, Shamim EA, Nnama A, Standaert D, Komolafe M, Dean M, Osaigbovo G, Disbrow E, Ishola I, Rawls A, Imarhiagbe F, Chandra S, Erameh C, Hinson V, Louie N, Idowu A, Solle J, Norris SA, Ibrahim A, Kilbane C, Sukumar G, Shulman LM, Ezuduemoih D, Staisch J, Breaux S, Dalgard C, Foster ER, Bello A, Ameri A, Real R, Ikwenu E, Morris HR, Anyanwu R, Stimming EF, Billingsley K, Alaofin W, Jerez PA, Agabi O, Hernandez DG, Akinyemi R, Arepalli S, Malik L, Owolabi R, Nyandaiti Y, Leonard HL, Wahab K, Step K, Abiodun O, Hernandez CF, Abdulai F, Iwaki H, Bardien S, Klein C, Hardy J, Houlden H, Galvelis KG, Nalls MA, Dahodwala N, Aamodt W, Hill E, Espay A, Factor S, Branson C, Blauwendraat C, Singleton AB, Ojo O, Chahine LM, Black and African American Connections to Parkinson’s Disease Study (BLAAC PD), Nigeria Parkinson’s Disease Research Network (NPDRN), Racial Disparities in Parkinson Disease (RaD-PD) and the Global Parkinson’s Genetics Program (GP2), Okubadejo N, Bandres-Ciga S
Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.
medRxiv. 2025 Jan 20; PubMed.PAPER Patowary P, Shakya A, Ghosh SK, Jamir L, Sahariah BJ, Gogoi N, Singh UP, Bhat HR
In Silico Study, Synthesis, and In Vitro Evaluation of Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity of Novel N-Thiazole Substituted Acetamide Coumarin Derivatives.
Chem Biodivers. 2025 Feb 4;:e202401524. Epub 2025 Feb 4 PubMed.Current Filters
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