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Gene Expression Signatures of Immaturity, Decreased pH, and Neural Hyperexcitation in the Hippocampus of Alzheimer's Disease Model Mice.

Neuropsychopharmacol Rep. 2025 Mar;45(1):e70001. PubMed.

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PAPER Anwar M, Renu K, Singh AK, Nayal A, Thyagarajan B, Hu P, Lee J, Dey S, Dey AB

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PAPER Lee N, Lee D, Lee JH, Lee BS, Kim S, Kim JH, Jeong S

Nanosensor-based imaging of realtime dopamine release in neurons derived from iPSCs of patients with Parkinson's disease.

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The impact of rare genetic variants on Alzheimer disease.

Nat Rev Neurol. 2025 Feb 4; Epub 2025 Feb 4 PubMed.

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Sci Rep. 2025 Feb 4;15(1):4193. PubMed.

PAPER Panza F, Dibello V, Sardone R, Zupo R, Castellana F, Leccisotti I, Moretti MC, Altamura M, Bellomo A, Daniele A, Solfrizzi V, Resta E, Lozupone M

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PAPER Möhwald LM, Maier A, Grehl T, Weyen U, Weydt P, Günther R, Lingor P, Göricke B, Petri S, Grosskreutz J, Boentert M, Cordts I, Weishaupt JH, Dorst J, Münch C, Meyer T, Baum P

Shared prognostic information in amyotrophic lateral sclerosis- systematic assessment of the patients' perception of neurofilament light chain and the ALS functional rating scale.

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The roles of functional bacterial amyloids in neurological physiology and pathophysiology: Pros and cons for neurodegeneration.

Microb Pathog. 2025 Feb 3;200:107363. Epub 2025 Feb 3 PubMed.

PAPER Ştefănescu R

Quantification of amyloid-β aggregation inhibitors gallic acid and rosmarinic acid in biological samples by LC-MS/MS.

Anal Biochem. 2025 Feb 4;700:115799. Epub 2025 Feb 4 PubMed.

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Yongchang Qiu

Lysoway Therapeutics, Inc.
United States

David Holtzman on From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check

COMMENT The meninges, especially the dura, contain a full repertoire of immune cells. However, there has been little work on the characterization and potential role of the T regulatory cell (Treg) compartment. In other organs, Tregs can restrain immune responses.

From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check

RESEARCH NEWS 2025-02-05 Research News Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls to a sparse population of regulatory T cel

Marco Colonna, Patrick Rodrigues on From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check

COMMENT This highly novel study provides fascinating insights into the role of regulatory T cells in maintaining brain homeostasis. The identification of a distinct meningeal Treg compartment that regulates interferon-gamma (IFN-γ) responses is particularly inter