338614 RESULTS
COMMENT In this paper, Green et al. use single-cell analyses of 1.6 million cells and the BEYOND framework, along with mediation modeling, to explore the cellular dynamics of AD. They attempt to distinguish the progression to AD (referred to as "prAD")
COMMENT This is one of four contemporary large-scale efforts to apply single-cell profiling to the neocortex in a cohort of AD donors. The other three are our own (coming out in November in Nature Neuroscience), Li-Huei Tsai’s in Cell last year, and Evan Macosko’
COMMENT This paper is a significant achievement. Along with recent datasets from the Allen Brain Institute and MIT, it represents the latest generation of Alzheimer's nuc-Seq atlases notable for the large number of samples and cells analyzed. The insights em
COMMENT This fascinating and timely study really deepens our understanding of cellular dynamics in aging and Alzheimer’s disease. The use of single-cell RNA-Seq on such a large cohort of brains is impressive and allows for an unprecedented look at the specific mi
RESEARCH NEWS 2024-09-26 Research News The amyloid cascade—plaques to tangles to cognitive decline—has become well established. Less well understood is what role inflammation and glial changes play. Now, by analyzing single-nuclei RNA-Seq data from more than 400 postmortem brains
COMMENT Belloy et al. performed an XWAS for AD by analyzing 15,081 clinical-AD cases, 41,091 registry-AD and Alzheimer’s disease and dementia (ADD) cases and 82,386 proxy-ADD cases. They identified a genome-wide significant (P<5x10-8) signal in the SLC9A7 locu
COMMENT In their timely and well-executed study, Belloy et al. conducted a large-scale X-chromosome-wide association study of the genetics of Alzheimer’s disease. Their approach is novel and much-anticipated because the X chromosome has been largely excluded in g
PAPER Fuller PE, Collis VL, Sharma P, Burkett AM, Wang S, Brown KA, Weir N, Goulbourne CN, Nixon RA, Longden TA, Gould TD, Monteiro MJ
JOB 2024-09-26 Employer University of Calgary Principal Investigator Sabine Gilch Contact Cover letter, CV, and contact details for three references should be sent to sgilch@ucalgary.ca Description The Sabine Gilch lab is seeking to recruit two postdoctoral researchers
Universitat Oberta de CatalunyaBarcelona, Spain
Aliada TherapeuticsBoston, United States
PAPER Gardiner K, Zhang X, Xing L
PAPER Lloyd C, Freskgård PO, Newton P, Lowne D, Nickson A, Bogstedt A, Eketjäll S, Höglund K, Gustavsson S, Welsh F, Chessell T, McFarlane M, Bhat RV, Turner R, Perkinton MS, Santisteban Valencia Z, Lindqvist E, Pomfret M, Dudley AD, Vaughan TJ, Groves MT, Natanegara F, Feng Y, Sims JR, Proctor NK, Dage JL, Shering C, Tan K, Ostenfeld T, Billinton A, Chessell IP
PAPER Magalhães R, Marques F, Selingue E, Boumezbeur F, Mériaux S, Sousa N
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