TREM2-mKATE2 Reporter Mouse

RESEARCH MODELS Summary In this mouse, TREM2 and the fluorescent protein mKate2 are co-expressed under the control of the endogenous Trem2 promoter, allowing researchers to indirectly assess expression of TREM2 by measuring mKate2 fluorescence (Feiten et al., 2024). Bici

Julie Williams on Large Neuropathology GWAS Finds Four New Dementia Genes

COMMENT Exploring relationships between biology and genetic susceptibility always provides valuable information to guide our understanding of disease mechanisms. Shade and colleagues present an interesting GWAS study of Alzheimer’s disease (AD), with neuropatholo

Vivek Swarup on Large Neuropathology GWAS Finds Four New Dementia Genes

COMMENT This paper improves on previous AD GWAS by focusing on neuropathological endophenotypes (NPEs) rather than clinical diagnoses, providing a more concrete look at specific brain pathologies, such as amyloid plaques and cerebrovascular changes. It identifies

Emerging Global Leader Award (K43 Independent Clinical Trial Required) (PAR-24-295)

GRANT Friday, October 18, 2024- 3:45pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-295.html 04 Dec 2026

Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed) (PAR-24-296)

GRANT Friday, October 18, 2024- 3:45pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-296.html 04 Dec 2026

PAPER Fertan E, Lam JY, Albertini G, Dewilde M, Wu Y, Akingbade OE, Boeken D, English EA, DeStrooper B, Klenerman D

Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab

bioRxiv2024.10.11.617910 .

Tau Global Conference

CONFERENCE 2025-04-24 00:00:00-2025-04-25 00:00:00 London, U.K. and Online 24 &#x2013 25 April 2025 0

PAPER Reas ET, Solders SK, Tsiknia A, Triebswetter C, Shen Q, Rivera CS, Andrews MJ, Alderson-Myers A, Brewer JB

APOE ϵ4-related blood-brain barrier breakdown is associated with microstructural abnormalities.

Alzheimers Dement. 2024 Oct 16; PubMed.

JAX Conference: Vascular Contributions to Cognitive Impairment and Dementia (VCID)

CONFERENCE 2025-05-12 00:00:00-2025-05-15 00:00:00 Bar Harbor, Maine and Online 12 &#x2013 15 May 2025 View Conference Website 0

Lindsay Rizzardi on Single-Cell Methylomes Offer Clues to Aging

COMMENT Over the past decade, there have been significant technological advancements in single-cell transcriptome and epigenome profiling, as well as in spatial transcriptomics and proteomics. These methods have been crucial in understanding altered gene regulati

PAPER Tegowski M, Flamand MN, Meyer KD

scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells.

Mol Cell. 2022 Feb 17;82(4):868-878.e10. Epub 2022 Jan 25 PubMed.

Lindsay Rizzardi

University of Alabama at Birmingham
Birmingham, United States

PAPER Zhang W, Ding F, Rong X, Ren Q, Hasegawa T, Liu H, Li M

Aβ-induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP/PS1 mice with Alzheimer's diseases.

Aging Cell. 2024 Oct 16;:e14374. PubMed.

PAPER Iannotta L, Fasiczka R, Favetta G, Zhao Y, Giusto E, Dall'Ara E, Wei J, Ho FY, Ciriani C, Cogo S, Tessari I, Iaccarino C, Liberelle M, Bubacco L, Taymans JM, Manzoni C, Kortholt A, Civiero L, Hilfiker S, Lu ML, Greggio E

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner.

Cell Death Dis. 2024 Oct 17;15(10):752. PubMed.

PAPER Lim SY, Pajo AT, Dy Closas AM, Hor J, Toh TS, Ngim SJ, Lim YZ, Tan AH

Differences in progressive supranuclear palsy in patients of Asian ancestry?

Parkinsonism Relat Disord. 2024 Oct 6;:107162. PubMed.