PAPER da Costa J, Perret, Buée, Hamdane, Martin

FTLD-MAPT mutations and short 5 UTR Tau mRNAs increase Tau translation

NAR Molecular Medicine, Volume 1, Issue 4, October 2024 Published: 10 December 2024 . https://doi.org/10.1093/narmme/ugae023

Michel Goedert, Sjors Scheres on New Biomarkers Catch Tau Before It Tangles

COMMENT Alzheimer’s disease, primary age-related tauopathy and several rarer neurodegenerative conditions are characterized by the intraneuronal assembly of all six brain tau isoforms into abnormal filaments of identical structure (Fitzpatrick et al., 2017; Halli

Michael Belloy on Impact of APOE, Klotho, and sex on cognitive decline with aging.

COMMENT This study represents an important addition to the ongoing research into the interaction of age, sex, Klotho-VS, and APOE4, on cognition and brain resilience. The authors leverage a large sample of cognitively normal subjects, ages 40-70, in the UK Bioban

Carmela Abraham on Impact of APOE, Klotho, and sex on cognitive decline with aging.

COMMENT This did not find any significant effects of Klotho-VS heterozygosity on cognitive function across aging, nor on brain gray matter volume in healthy individuals. These data do not confirm previous findings that reported improved memory and executive funct

PAPER Abraham CR, Li A

Aging-suppressor Klotho: Prospects in diagnostics and therapeutics.

Ageing Res Rev. 2022 Dec;82:101766. Epub 2022 Oct 22 PubMed.

Hermona Soreq on Impact of APOE, Klotho, and sex on cognitive decline with aging.

COMMENT The longevity gene Klotho enhances cognition prolongs lifespan in mice and humans (Kuro-o et al., 2009). Leveraging data from the UK Biobank, Shibata et al. challenge this notion, demonstrating that carriers of the “protective” Klotho-VS haplotype, which

PAPER Kuro-o M

Klotho and aging.

Biochim Biophys Acta. 2009 Oct;1790(10):1049-58. Epub 2009 Feb 20 PubMed.

Michael Ewers on Impact of APOE, Klotho, and sex on cognitive decline with aging.

COMMENT This study examined the sex-dependent effects of APOE ε4 genotype and a KLOTHO haplotype on aging-associated differences in cognitive performance. It stands out for testing the genetic associations in a large sample including more than 350 000 subjects be

Emil Uffelmann on Expanded Repeat Sequences Raise a Person’s Risk for Alzheimer’s

COMMENT This study examined the relationship between short tandem repeat (STR) expansions, a frequently overlooked type of genetic variation, and the risk of AD. While one STR was significantly associated with AD risk, its association could be almost fully accoun

Natalie King

Rafael Patarra

Systasy Bioscience
Germany

PAPER Krüger C, Lim SY, Buhrmann A, Fahrig FL, Gabbert C, Bahr N, Madoev H, Marras C, Klein C, Lohmann K

Updated MDSGene review on the clinical and genetic spectrum of LRRK2 variants in Parkinson´s disease.

NPJ Parkinsons Dis. 2025 Feb 17;11(1):30. PubMed.

PAPER Turnbull J

Platform Trials in ALS.

JAMA. 2025 Feb 17; Epub 2025 Feb 17 PubMed.

PAPER Mombaur B, Dias K

Patient Navigation in Amyotrophic Lateral Sclerosis (ALS): A Potential Approach to Timely Diagnosis.

J Health Care Poor Underserved. 2025;36(1):361-374. PubMed.

PAPER Feng YY, Hao JR, Zhang YJ, Qiu TT, Zhang ML, Qiao W, Wu JJ, Qiu P, Xu CF, Zhang YL, Du CY, Pan Z, Chang YS

Krüppel-like factor 9 alleviates Alzheimer's disease via IDE-mediated Aβ degradation.

Acta Pharmacol Sin. 2025 Feb 17; Epub 2025 Feb 17 PubMed.