Dorota Religa

Karolinska Institutet
Sweden

News Brief: ALS Drug Olesoxime Fails in Phase 3 Trial

RESEARCH NEWS 2011-12-16 Research News While modulating mitochondrial activity to protect neurons may be a route to treat amyotrophic lateral sclerosis, olesoxime is apparently not the way to get there. Researchers hoped that the cholesterol-like small molecule, tested by the pha

Research Brief: Evidence Supports Model of AD Biomarker Progression

RESEARCH NEWS 2011-12-16 Research News A popular model of Alzheimer’s disease progression proposes an ordered sequence by which the main biomarkers change: β amyloid first, then tau, followed by hippocampal volume and cognitive function (see ARF Webinar). Researchers led by Cliff

Does Brain Hypoxia Help Kick Off Alzheimer’s Pathology?

RESEARCH NEWS 2011-12-16 Research News Why some seniors develop sporadic Alzheimer’s disease and others do not is still largely a mystery. Now, two new human studies implicate loss of oxygen in the brain as a possible culprit that touches off early AD pathology. In the December 1

Did MicroRNAs Orchestrate the Human Brain Boom?

RESEARCH NEWS 2011-12-16 Research News Humankind may owe its outsized intelligence to our microRNAs. The activity of these tiny gene regulators during brain development distinguishes us from our furrier, less brilliant primate cousins, according to a paper in the December 6 PLoS

PAPER Cabeza-Arvelaiz Y, Fleming SM, Richter F, Masliah E, Chesselet MF, Schiestl RH

Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons.

Mol Neurodegener. 2011 Dec 13;6:83. PubMed.

PAPER Taschenberger G, Garrido M, Tereshchenko Y, Bähr M, Zweckstetter M, Kügler S

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.

Acta Neuropathol. 2011 Dec 14; PubMed.

PAPER Duncan GW

The aging brain and neurodegenerative diseases.

Clin Geriatr Med. 2011 Nov;27(4):629-44. PubMed.

PAPER Krames E, Buchser E, Hassenbusch SJ, Levy R

Future trends in the development of local drug delivery systems: intraspinal, intracerebral, and intraparenchymal therapies.

Neuromodulation. 1999 Apr;2(2):133-48. PubMed.

PAPER Preston GC, Brazell C, Ward C, Broks P, Traub M, Stahl SM

The scopolamine model of dementia: determination of central cholinomimetic effects of physostigmine on cognition and biochemical markers in man.

J Psychopharmacol. 1988 Jan;2(2):67-79. PubMed.

PAPER Mohamd EM, Ahmed HH, Estefan SF, Farrag AE, Salah RS

Windows into estradiol effects in Alzheimer's disease therapy.

Eur Rev Med Pharmacol Sci. 2011 Oct;15(10):1131-40. PubMed.

PAPER Byun CJ, Seo J, Jo SA, Park YJ, Klug M, Rehli M, Park MH, Jo I

DNA methylation of the 5'-untranslated region at +298 and +351 represses BACE1 expression in mouse BV-2 microglial cells.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):387-92. PubMed.

PAPER Blount JW, Ferruzzi M, Raftery D, Pasinetti GM, Dixon RA

Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):457-61. PubMed.

PAPER Chen LM, Lin ZY, Zhu YG, Lin N, Zhang J, Pan XD, Chen XC

Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells.

Eur J Pharmacol. 2012 Jan 30;675(1-3):15-21. PubMed.

PAPER Kim JL, Park JH, Kim BJ, Kim MD, Kim SK, Chi YK, Kim TH, Moon SW, Park MH, Bae JN, Woo JI, Ryu SH, Yoon JC, Lee NJ, Lee DY, Lee DW, Lee SB, Lee JJ, Lee CU, Chang SM, Han JW, Jhoo JH, Han C, Cho MJ, Kim KW

Interactive influences of demographics on the Mini-Mental State Examination (MMSE) and the demographics-adjusted norms for MMSE in elderly Koreans.

Int Psychogeriatr. 2011 Dec 14;:1-9. PubMed.