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Trontinemab Data Strengthen Hope for Brain Shuttles

CONFERENCE COVERAGE 2024-11-08 Conference Coverage Fewer than 1 percent of amyloid-targeted monoclonal antibodies like lecanemab and donanemab reach their targets in the brain. The excess doses required to make up for this problem raise the risk of hazardous brain bleeding, reflected i

That Mystery “Density” in α-Syn Fibrils: Polyphosphate, Anyone?

RESEARCH NEWS 2024-11-08 Research News In recent years, CryoEM has enabled scientists to decipher the structures of the fibrils that form various deposits in neurodegenerative disease. They have not only solved disease-specific folding structures for fibrils of Aβ, tau, TDP-43, T

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