EMBO|FEBS- Molecular Mechanisms of Ageing and Regeneration: From Hydra to Humans

CONFERENCE 2024-09-05 00:00:00-2024-09-12 00:00:00 Spetses, Greece 05 &#x2013 12 September 2024 View Conference Website 0

International Symposium in Georgia on Cognitive Disorders- 1st

CONFERENCE 2024-09-05 00:00:00-2024-09-08 00:00:00 Tbilisi, Georgia 05 &#x2013 08 September 2024 View Conference Website 0

Australasian Winter Conference on Brain Research (AWCBR) 2024

CONFERENCE 2024-08-31 00:00:00-2024-09-04 00:00:00 Queenstown, New Zealand 31 August &#x2013 04 September 2024 View Conference Website 0

PAPER Freitag K, Sterczyk N, Schulz J, Houtman J, Fleck L, Sigrist SJ, Heppner FL, Jendrach M

The autophagy activator Spermidine ameliorates Alzheimer's disease pathology and neuroinflammation in mice

bioRxiv2020.12.27.424477 .

Transcriptomics Paint Astrocytes as Source of Cognitive Resilience

RESEARCH NEWS 2024-07-26 Research News Single-cell transcriptomics aficionados have raised the bar again. In a study published in Nature on July 24, scientists led by Li-Huei Tsai and Manolis Kellis at Massachusetts Institute of Technology, Cambridge, parsed the transcriptomes of

PAPER Mathys H, Boix CA, Akay LA, Xia Z, Davila-Velderrain J, Ng AP, Jiang X, Abdelhady G, Galani K, Mantero J, Band N, James BT, Babu S, Galiana-Melendez F, Louderback K, Prokopenko D, Tanzi RE, Bennett DA, Tsai LH, Kellis M

Single-cell multiregion dissection of Alzheimer’s disease

Nature, July 24, 2024 . Nature.

American Academy of Neurology (AAN) Fall Conference

CONFERENCE 2024-10-25 00:00:00-2024-10-27 00:00:00 Las Vegas, Nevada and Online 25 &#x2013 27 October 2024 View Conference Website 0

The Science of Alzheimer’s & Infectious Diseases Symposium

CONFERENCE 2024-10-15 00:00:00-2024-10-15 00:00:00 Los Angeles, California 15 October 2024 View Conference Website 0

Oskar Hansson on Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy

COMMENT This is a very comprehensive study, which was done in a careful manner by experts in the field. I have only one major concern, and that is how A plaques and tau tangle pathology are compared to flortaucipir retention. The flortaucipir PET signal is quant

Rik Ossenkoppele on Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy

COMMENT This is an excellent and important study reporting on the largest antemortem tau PET (combined with amyloid PET) versus autopsy dataset to date. The main goal of the study was to investigate the relationships between tau and amyloid pathology based on inf

sam ahasan

Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy

RESEARCH NEWS 2024-07-25 Research News Tau PET has become a valuable research tool, but questions remain about how well tracer uptake reflects underlying tangles, how plaques influence this relationship, and how effectively the scans could be used for diagnosis. In the July 24 Sc

PAPER Josephs KA, Tosakulwong N, Weigand SD, Graff-Radford J, Schwarz CG, Senjem ML, Machulda MM, Kantarci K, Knopman DS, Nguyen A, Reichard RR, Dickson DW, Petersen RC, Lowe VJ, Jack CR Jr, Whitwell JL

Flortaucipir PET uncovers relationships between tau and amyloid-β in primary age-related tauopathy and Alzheimer's disease.

Sci Transl Med. 2024 Jul 24;16(757):eado8076. PubMed.

Julia TCW on Part with PILRA, Power Up Microglia?

COMMENT Monroe, Blurton-Jones, and colleagues report on one of the myeloid-specific genetic targets, PILRA, that modulates AD risk. PILRA knockout microglia display lipid droplet accumulation but maintain homeostasis in an inflammatory environment by showing incr

PAPER Talari NK, Mattam U, Meher NK, Paripati AK, Mahadev K, Krishnamoorthy T, Sepuri NB

Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats.

Nat Commun. 2023 Feb 11;14(1):766. PubMed.