Research Models

Selected Results

1 Models

Name Other Names Strain Name Genetic Background Gene Mutation Modification Info Modification Disease Neuropathology Behavior/Cognition Other Phenotype Availability Primary Paper Visualization
Mouse Models (1)
C57Bl/6J Trem2 TREM2 H157Y CRISPR/Cas9 gene editing was used to introduce the H157Y mutation into the mouse Trem2 gene. Trem2: Knock-In Alzheimer's Disease Microglial density and morphology did not differ between carriers of the H157Y variant and wild-type mice. Trem2-H157Y knock-in did not differ from wild-type mice at 6 months of age in tests of anxiety, associative memory, and spatial working memory. Enhanced hippocampal synaptic plasticity was observed in mice homozygous for the H157Y variant, compared with wild-type mice. Available through Na Zhao (zhao.na@mayo.edu). Qiao et al., 2023 Yes

1 Visualizations

AD-related Research Models

Phenotypes Examined

  • Plaques
  • Tangles
  • Neuronal Loss
  • Gliosis
  • Synaptic Loss
  • Changes in LTP/LTD
  • Cognitive Impairment

When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.

Trem2-H157Y knock-in

Observed
  1. X
    Changes in LTP/LTD at 24

    Enhanced paired-pulse facilitation and long-term potentiation at Schaffer collateral-CA1 synapses in 6-month-old mice homozygous for the H157Y Trem2 allele.

Absent
  • Gliosis at

    Microglial density and morphology did not differ between carriers of the H157Y variant and wild-type mice at 6 months of age.

  • Synaptic Loss at

    Levels of the presynaptic marker synaptophysin and the postsynaptic markers PSD95 and GLUR2 in the cortices of 6-month-old mice did not differ between carriers of the H157Y variant and wild-type mice.

  • Cognitive Impairment at

    The H157Y mutation did not affect the performances of 6-month-old mice on a battery of behavioral tests: the open-field test to assess anxiety, cued and contextual fear conditioning to measure associative memory, and the Y-maze test to measure spatial working memory.

No Data
  • Plaques at

    No data.

  • Tangles at

    No data.

  • Neuronal Loss at

    No data.

Genes Mutations Modification Disease Neuropathology Behavior/Cognition
Trem2 TREM2 H157Y Trem2: Knock-In Alzheimer's Disease

Microglial density and morphology did not differ between carriers of the H157Y variant and wild-type mice.

Trem2-H157Y knock-in did not differ from wild-type mice at 6 months of age in tests of anxiety, associative memory, and spatial working memory.

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