Qiao W, Chen Y, Zhong J, Madden BJ, Charlesworth CM, Martens YA, Liu CC, Knight J, Ikezu TC, Aishe K, Zhu Y, Meneses A, Rosenberg CL, Kuchenbecker LA, Vanmaele LK, Li F, Chen K, Shue F, Dacquel MV, Fryer J, Pandey A, Zhao N, Bu G. Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Mol Neurodegener. 2023 Jan 31;18(1):8. PubMed. Correction.

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Research Models

  1. Trem2-H157Y knock-in
  2. Trem2-H157Y x 5xFAD
  3. AAV-sTREM2 5xFAD
  4. AAV-sTREM2 PS19