Research Models

APOE4 Targeted Replacement

Synonyms: APOE4 Humanized Knock-in

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Species: Mouse
Genes: APOE
Mutations: APOE C130R (ApoE4)
Modification: APOE: Knock-In
Disease Relevance: Alzheimer's Disease, Multiple Conditions
Strain Name: B6.129P2-Apoetm3(APOE*4)Mae N8
Genetic Background: 129 x C57BL/6, back-crossed to C57BL/6
Availability: Taconic: Stock# 1549-F or 1549-M

Summary

The APOE4 Targeted Replacement model is one line in a set of three APOE knock-in lines created by Nobuyo Maeda, Patrick Sullivan, and colleagues. APOE2 and APOE3 Targeted Replacement mice are also available. A detailed description of these lines can be found on the APOE3 Targeted Replacement page.

 

Last Updated: 30 Aug 2024

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References

Research Models Citations

  1. APOE2 Targeted Replacement
  2. APOE3 Targeted Replacement

External Citations

  1. Taconic: Stock# 1549-F or 1549-M

Further Reading

Papers

  1. Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010 Oct 13;30(41):13707-17. PubMed.
  2. Sullivan PM, Mace BE, Maeda N, Schmechel DE. Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. Neuroscience. 2004;124(4):725-33. PubMed.