Llorens F, Thüne K, Tahir W, Kanata E, Diaz-Lucena D, Xanthopoulos K, Kovatsi E, Pleschka C, Garcia-Esparcia P, Schmitz M, Ozbay D, Correia S, Correia Â, Milosevic I, Andréoletti O, Fernández-Borges N, Vorberg IM, Glatzel M, Sklaviadis T, Torres JM, Krasemann S, Sánchez-Valle R, Ferrer I, Zerr I. YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias. Mol Neurodegener. 2017 Nov 10;12(1):83. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(84)		 366 ± 302
pg/mL		 ELISA;
Innotest AMYLOID (1–42);
Fujirebio		 1991
Aβ42
(CSF)		 CTRL-
Other Controls
(62)		 884 ± 321
pg/mL		 ELISA;
Innotest AMYLOID (1–42);
Fujirebio
Aβ42
(CSF)		 VaD
(20)		 543 ± 203
pg/mL		 ELISA;
Innotest AMYLOID (1–42);
Fujirebio		 Román et al., 1993; 1991
YKL-40
(CSF)		 AD
(28)		 311 ± 113
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation		 McKhann et al., 1984
YKL-40
(CSF)		 AD
(84)		 386 ± 221
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation		 1991
YKL-40
(CSF)		 CTRL-
Other Controls
(62)		 250 ± 77
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation
YKL-40
(CSF)		 CTRL
(35)		 226 ± 82
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation
YKL-40
(CSF)		 VaD
(20)		 323 ± 96
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation		 Román et al., 1993; 1991
YKL-40
(CSF)		 gCJD-
E200K
(11)		 471 ± 135
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation		 Zerr et al., 2009
YKL-40
(CSF)		 gCJD-
E200K
(11)		 447 ± 161
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation		 Zerr et al., 2009
YKL-40
(CSF)		 sCJD
(35)		 411 ± 157
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation		 Zerr et al., 2009
YKL-40
(CSF)		 sCJD
(82)		 480 ± 178
pg/mL		 ELISA;
MicroVue YKL-40 EIA;
Quidel Corporation		 Zerr et al., 2009
tau-total
(CSF)		 AD
(28)		 757 ± 505
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio		 McKhann et al., 1984
tau-total
(CSF)		 AD
(84)		 511 ± 429
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio		 1991
tau-total
(CSF)		 CTRL-
CNC
(35)		 221 ± 121
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio
tau-total
(CSF)		 CTRL-
Other Controls
(62)		 259 ± 124
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio
tau-total
(CSF)		 FFI
(11)		 425 ± 411
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio		 Zerr et al., 2009
tau-total
(CSF)		 VaD
(20)		 435 ± 309
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio		 Román et al., 1993; 1991
tau-total
(CSF)		 gCJD-
E200K
(11)		 4323 ± 4069
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio		 Zerr et al., 2009
tau-total
(CSF)		 gCJD-
E200K
(11)		 2452 ± 1777
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio		 Zerr et al., 2009
tau-total
(CSF)		 sCJD
(35)		 3688 ± 3532
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio		 Zerr et al., 2009
tau-total
(CSF)		 sCJD
(82)		 9622 ± 8468
pg/mL		 ELISA;
Innotest hTAU Ag;
Fujirebio		 Zerr et al., 2009

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This paper appears in the following:

AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. VaD vs AD : Aβ42 (CSF)
  4. AD vs CTRL : YKL-40 (CSF)
  5. CTRL vs AD : YKL-40 (CSF)
  6. VaD vs AD : YKL-40 (CSF)
  7. gCJD vs AD : YKL-40 (CSF)
  8. sCJD vs AD : YKL-40 (CSF)
  9. AD vs CTRL : tau-total (CSF)
  10. CTRL vs AD : tau-total (CSF)
  11. FFI vs AD : tau-total (CSF)
  12. VaD vs AD : tau-total (CSF)
  13. gCJD vs AD : tau-total (CSF)
  14. sCJD vs AD : tau-total (CSF)