Motter R, Vigo-Pelfrey C, Kholodenko D, Barbour R, Johnson-Wood K, Galasko D, Chang L, Miller B, Clark C, Green R. Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol. 1995 Oct;38(4):643-8. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(37)		 383 ± 76
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(20)		 632 ± 156
pg/mL		 ELISA;
Other/Not Specified;
In-house
tau-total
(CSF)		 AD
(37)		 543 ± 177
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(20)		 212 ± 102
pg/mL		 ELISA;
Other/Not Specified;
In-house

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This paper appears in the following:

Research Timeline Event

  1. AD signature found in CSF: tau increased, Aβ42 decreased

AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. AD vs CTRL : tau-total (CSF)
  4. CTRL vs AD : tau-total (CSF)